https://scholars.lib.ntu.edu.tw/handle/123456789/494886
標題: | Predictive value of PD-L1 and other clinical factors for chemoimmunotherapy in advanced non-small-cell lung cancer | 作者: | Woodford R Loh Y Lee J Cooper W Marschner I Lewis C.R Millward M Lord S Gralla R.J CHIH-HSIN YANG Mok T Lee C.K. |
關鍵字: | chemoimmunotherapy; meta-analysis; non-small-cell lung cancer; PD-L1 expression; progression-free survival | 公開日期: | 2019 | 出版社: | Future Medicine Ltd. | 卷: | 15 | 期: | 20 | 起(迄)頁: | 2371-2383 | 來源出版物: | Future Oncology | 摘要: | We investigate if PD-L1 expression and other clinical characteristics predict chemoimmunotherapy (CIT) benefits versus chemotherapy in advanced non-small-cell lung cancer. We performed a meta-analysis of randomized controlled trials of CIT versus chemotherapy identified through electronic searches. In seven randomized controlled trials (n = 4170), CIT prolonged progression-free survival over chemotherapy (hazard ratio [HR]: 0.62; 95% CI: 0.58-0.67; p < 0.00001). The treatment benefits differed between PD-L1-high (HR: 0.41; 95% CI: 0.34-0.49) and PD-L1 low (HR: 0.63; 95% CI: 0.55-0.72; interaction-p = 0.00002) and PD-L1-high and PD-L1-negative (HR: 0.72; 95% CI: 0.65-0.80; interaction-p < 0.00001). Similar benefits were observed regardless of gender, EGFR/ALK status and histological subtype. PD-L1 status is predictive of CIT benefit and may assist patient selection and design of future trials. ? 2019 Future Medicine Ltd. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85070102898&doi=10.2217%2ffon-2019-0105&partnerID=40&md5=24d2ec5b2712ff542d343540f85fafe0 https://scholars.lib.ntu.edu.tw/handle/123456789/494886 |
ISSN: | 1479-6694 | DOI: | 10.2217/fon-2019-0105 | SDG/關鍵字: | anaplastic lymphoma kinase; atezolizumab; bevacizumab; carboplatin; cisplatin; durvalumab; epidermal growth factor receptor; gemcitabine; nivolumab; paclitaxel; pembrolizumab; pemetrexed; programmed death 1 ligand 1; antineoplastic agent; CD274 protein, human; immunological antineoplastic agent; programmed death 1 ligand 1; cancer immunotherapy; clinical feature; gender; hazard ratio; histopathology; human; meta analysis; non small cell lung cancer; overall survival; patient selection; phase 3 clinical trial (topic); predictive value; priority journal; progression free survival; protein expression; randomized controlled trial (topic); Review; systematic review; treatment outcome; cancer staging; lung tumor; metabolism; mortality; non small cell lung cancer; pathology; sex factor; Antineoplastic Agents, Immunological; Antineoplastic Combined Chemotherapy Protocols; B7-H1 Antigen; Carcinoma, Non-Small-Cell Lung; Humans; Lung Neoplasms; Neoplasm Staging; Patient Selection; Progression-Free Survival; Randomized Controlled Trials as Topic; Sex Factors |
顯示於: | 腫瘤醫學研究所 |
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