https://scholars.lib.ntu.edu.tw/handle/123456789/495042
標題: | Neoadjuvant chemotherapy with docetaxel-cisplatin in patients with stage III N2 non-small-cell lung cancer | 作者: | WEI-YU LIAO Chen J.-H. Wu M. JIN-YUAN SHIH KUAN-YU CHEN CHAO-CHI HO CHIH-HSIN YANG CHONG-JEN YU |
公開日期: | 2013 | 卷: | 14 | 期: | 4 | 起(迄)頁: | 418-424 | 來源出版物: | Clinical Lung Cancer | 摘要: | Introduction: To assess the efficacy and potential prognostic factors of patients with stage III N2 non-small-cell lung cancer (NSCLC) treated with neoadjuvant docetaxel-cisplatin (DP) chemotherapy followed by surgical resection. Methods: Sixty-two patients with NSCLC treated with DP as neoadjuvant chemotherapy between November 2003 and December 2009 were identified and reviewed in this study. Tumor response, survival, and clinicopathologic data were collected retrospectively. The time to event was analyzed by fitting Cox proportional hazards models. Results: Fifty-eight (94%) of 62 patients eventually underwent surgical resection after DP. The overall clinical response rate to induction DP chemotherapy was 42%. Patients with squamous cell carcinoma (SCC) histology were more likely to response to the DP regimen than those with adenocarcinoma histology (68% vs. 33%, P =.006). With a median follow-up of 82.4 months among the 58 patients, there were 41 (71%) tumor relapses and 27 (47%) deaths. The median event-free survival was 27.5 months (95% CI, 22.3-32.7 months), and the median overall survival was 66.7 months (95% CI, 35.1-98.3 months). In multivariate analysis, when fitting the Cox proportional hazards model, SCC histology (hazard ratio [HR] 0.234 [95% CI, 0.098-0.560]; P =.001) and mediastinal downstaging to N0 (HR 0.451 [95% CI, 0.226-0.898]; P =.024) were independent predictors of better event-free survival. Conclusions: Neoadjuvant chemotherapy with the DP regimen is both active and well tolerated in patients with stage III N2 NSCLC. SCC histology predicted a better treatment response and survival outcome than adenocarcinoma histology in this patient group. Further investigation of combined-modality treatment is warranted to improve survival in the adenocarcinoma subset of stage III N2 NSCLC. ? 2013 Elsevier Inc. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84878774286&doi=10.1016%2fj.cllc.2012.10.003&partnerID=40&md5=50c4b1b8b536b6db460c2fd9b337e142 https://scholars.lib.ntu.edu.tw/handle/123456789/495042 |
ISSN: | 1525-7304 | DOI: | 10.1016/j.cllc.2012.10.003 | SDG/關鍵字: | cisplatin; docetaxel; UFT; adult; aged; alopecia; anemia; article; cancer adjuvant therapy; cancer combination chemotherapy; cancer prognosis; cancer radiotherapy; cancer recurrence; cancer surgery; diarrhea; disease severity; drug efficacy; event free survival; fatigue; female; follow up; histopathology; human; leukopenia; lung non small cell cancer; major clinical study; male; nail disease; nausea; outcome assessment; overall survival; retrospective study; squamous cell carcinoma; survival rate; treatment response; vomiting; Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Chemotherapy, Adjuvant; Cisplatin; Female; Follow-Up Studies; Humans; Lung Neoplasms; Lymphatic Metastasis; Male; Mediastinum; Middle Aged; Neoadjuvant Therapy; Neoplasm Recurrence, Local; Neoplasm Staging; Prognosis; Retrospective Studies; Survival Rate; Taxoids |
顯示於: | 腫瘤醫學研究所 |
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