https://scholars.lib.ntu.edu.tw/handle/123456789/495084
標題: | Skin manifestations of gefitinib and the association with survival of advanced non-small-cell lung cancer in Taiwan | 作者: | Wang, Shiou-Han CHIH-HSIN YANG HSIEN-CHING CHIU Hu, Fu-Chang CHIH-CHIEH CHAN YI-HUA LIAO Chen, Hsiao-Chin CHIA-YU CHU |
關鍵字: | Gefitinib; Non-small-cell lung cancer; Paronychia; Predictive factor; Skin toxicities (cutaneous adverse reactions) | 公開日期: | 2011 | 卷: | 29 | 期: | 1 | 起(迄)頁: | 13-18 | 來源出版物: | Dermatologica Sinica | 摘要: | Background: Epidermal growth factor receptor antagonists, such as gefitinib, erlotinib, and cetuximab, have been used in treating carcinomas. The efficacies have been proposed to correlate with skin reactions, but the most important predictive indicator is still unknown. Our aim was to investigate the types of skin toxicities and to analyze the major therapeutic predictive indicators in Taiwan. Methods: A retrospective analysis was used to study 68 patients with advanced non-small-cell lung cancer receiving gefitinib. Results: Acneiform eruption (41.2%), xerosis (38.2%), pruritus (26.5%), and paronychia (16.2%) composed most of the skin reactions. The univariate analysis revealed paronychia as the most substantial survival predictive indicator (p = 0.0427). In the multivariate analysis, older patients with paronychia had better prognosis (p = 0.0050). Women tended to develop paronychia (p = 0.1098). Xerosis positively correlated with paronychia (p = 0.0082). Conclusion: Paronychia is the most indicative survival predictive factor among the skin manifestations, and it correlates with age, gender, and xerosis. Elucidation of the relationship between cutaneous reactions can provide information on the epidermal growth factor receptor signaling mechanism of skin. Copyright ? 2011, Taiwanese Dermatological Association. Published by Elsevier Taiwan LLC. All rights reserved. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-79954423619&doi=10.1016%2fj.dsi.2011.02.003&partnerID=40&md5=c061f769b7557fc84dd866b87cbf1fd2 https://scholars.lib.ntu.edu.tw/handle/123456789/495084 |
ISSN: | 1027-8117 | DOI: | 10.1016/j.dsi.2011.02.003 | SDG/關鍵字: | gefitinib; acne; adult; advanced cancer; aged; alopecia; article; cancer survival; female; folliculitis; high risk population; human; lung non small cell cancer; major clinical study; male; mouth ulcer; paronychia; petechia; prognosis; pruritus; sex difference; single drug dose; skin manifestation; Taiwan; xerosis |
顯示於: | 腫瘤醫學研究所 |
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