https://scholars.lib.ntu.edu.tw/handle/123456789/495111
標題: | Gemcitabine plus conventional-dose epirubicin versus gemcitabine plus cisplatin as first-line chemotherapy for stage IIIB/IV non-small cell lung carcinoma-A randomized phase II trial | 作者: | CHIUN HSU SUNG-HSIN KUO Hu F.-C. ANN-LII CHENG JIN-YUAN SHIH CHONG-JEN YU CHIA-CHI LIN Huang T.-C. PAN-CHYR YANG CHIH-HSIN YANG |
公開日期: | 2008 | 卷: | 62 | 期: | 3 | 起(迄)頁: | 334-343 | 來源出版物: | Lung Cancer | 摘要: | Background: Epirubicin was effective for the treatment of non-small cell lung carcinoma (NSCLC). This study compared the efficacy and safety of gemcitabine plus conventional-dose epirubicin (GE) with gemcitabine-cisplatin (GC) as first-line chemotherapy for stage IIIB/IV NSCLC and evaluated the predictive value of nuclear expression of excision repair cross-complementing group 1 (ERCC1) and topoisomerase IIα (TopoIIα) on treatment outcome. Patients and methods: Patients were randomized to GE (gemcitabine, 1000 mg/m2 on days 1, 8, and 15 and epirubicin, 70 mg/m2 on day 15) or GC (gemcitabine, 1000 mg/m2 on days 1, 8, and 15 and cisplatin, 80 mg/m2 on day 15). Treatment cycles were repeated every 4 weeks. Immunohistochemical study of ERCC1 and TopoIIα was done for patients with available tumor specimens. Results: The response rate was 31.0% (95% CI 16.4-45.5%) for GC (n = 41) and 37.2.0% (95% CI 22.2-52.3%) for GE (n = 39). No significant differences in median time-to-treatment-failure (TTF) (GC, 6.1 months; GE, 6.2 months) or overall survival (GC, 13.2 months; GE, 21.5 months) were found between the two arms. Grade 3/4 neutropenia and febrile neutropenia were more common in GE. However, delay of protocol treatment due to leukopenia was similar between the two arms. Patients with expression of both ERCC1 and TopoIIα had a significantly shorter TTF (median 2.4 months, 95% CI 0.7-4.1 months) than other patients (median 8.8 months, 95% CI 5.8-11.8 months) (p = 0.04). Conclusion: GE regimen is effective and well-tolerated for NSCLC patients. Expression of both ERCC1 and TopoIIα may be associated with poor response to chemotherapy. ? 2008 Elsevier Ireland Ltd. All rights reserved. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-45849137388&doi=10.1016%2fj.lungcan.2008.03.010&partnerID=40&md5=bb37dfbdd971c43310617f87223e4832 https://scholars.lib.ntu.edu.tw/handle/123456789/495111 |
ISSN: | 0169-5002 | DOI: | 10.1016/j.lungcan.2008.03.010 | SDG/關鍵字: | cisplatin; DNA topoisomerase (ATP hydrolysing); epirubicin; excision repair cross complementing protein 1; gemcitabine; alopecia; anemia; article; backache; cancer patient; cancer staging; cancer survival; clinical trial; constipation; controlled clinical trial; controlled study; diarrhea; drug dose reduction; drug efficacy; drug safety; febrile neutropenia; fever; hiccup; human; human tissue; immunohistochemistry; infection; leukopenia; lung non small cell cancer; mucosa inflammation; multiple cycle treatment; nausea; neurotoxicity; neutropenia; phase 2 clinical trial; priority journal; side effect; survival time; thrombocytopenia; treatment outcome; vomiting; weight reduction; Adenocarcinoma; Adult; Aged; Antigens, Neoplasm; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Large Cell; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Cisplatin; Deoxycytidine; DNA Topoisomerases, Type II, Eukaryotic; DNA-Binding Proteins; Endonucleases; Epirubicin; Female; Humans; Immunoenzyme Techniques; Lung Neoplasms; Male; Maximum Tolerated Dose; Middle Aged; Neoplasm Staging; Prognosis; Survival Rate; Treatment Outcome |
顯示於: | 腫瘤醫學研究所 |
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