Fixed erythrodysaesthesia plaque due to intravenous injection of docetaxel
Journal
British Journal of Dermatology
Journal Volume
142
Journal Issue
4
Pages
808-811
Date Issued
2000
Author(s)
Abstract
Docetaxel (Taxotere?), a semisynthetic taxoid, acts as an antimicrotubule agent and is considered to have great potential in the treatment of non-small cell lung cancer, advanced breast cancer, ovarian cancer and some other tumours. Well-recognized side-effects include dose- limiting neutropenia, fluid retention, myalgia, neuropathy, hypersensitivity reaction, alopecia, mucositis, nail changes and cutaneous reactions such as acral erythema. We describe a unique docetaxel-induced cutaneous reaction presenting as fixed erythematous plaque(s) unrelated to extravasation or previous skin injury; histopathological studies were performed in three of the four cases.
SDGs
Other Subjects
docetaxel; advanced cancer; alopecia; article; breast carcinoma; case report; drug hypersensitivity; drug induced disease; erythrodysesthesia; female; fluid retention; human; human tissue; lung adenocarcinoma; lung non small cell cancer; male; mucosa inflammation; myalgia; neutropenia; ovary carcinoma; priority journal; skin defect; Adult; Antineoplastic Agents, Phytogenic; Drug Eruptions; Erythema; Female; Humans; Injections, Intravenous; Male; Middle Aged; Paclitaxel; Paresthesia
Type
journal article