https://scholars.lib.ntu.edu.tw/handle/123456789/495214
標題: | Meta-prediction of MTHFR gene polymorphism and air pollution on the risks of congenital heart defects worldwide: A transgenerational analysis | 作者: | HSIAO-LING YANG YA-LING YANG Yu C.H. Shiao S.P.K. |
公開日期: | 2018 | 卷: | 15 | 期: | 8 | 起(迄)頁: | 1660 | 來源出版物: | International Journal of Environmental Research and Public Health | 摘要: | Congenital heart disease (CHD) is the leading cause of death in children, and is affected by genetic and environmental factors. To investigate the association of air pollution with methylene-tetrahydrofolate reductase (MTHFR) polymorphisms and the risk of CHD, we included 58 study groups of children and parents, with 12,347 cases and 18,106 controls worldwide. Both MTHFR C677T (rs 1801133) and A1298C (rs 1801131) gene polymorphisms were risks for CHD in children with transgenerational effects from their parents. Countries with greater risks of CHD with a pooled risk ratio (RR) > 2 from MTHFR 677 polymorphisms included Germany, Portugal, China, and Egypt for children; and Brazil, Puerto Rico, Mexico, China, and Egypt for mothers. Whereas, countries with greater risk of CHD with RR > 2 from MTHFR 1298 polymorphisms included Taiwan, Turkey, and Egypt for children; and Brazil, China, and Egypt for mothers. Additionally, meta-prediction analysis revealed that the percentages of MTHFR 677TT and TT plus CT polymorphisms together were increased in countries with higher levels of air pollution, with a trend of increased CHD risks with higher levels of air pollution for children (p = 0.07). Our findings may have significant implications for inflammatory pathways in association with MTHFR polymorphisms and future intervention studies to correct for folate-related enzyme deficits resultied from MTHFR polymorphisms to prevent CHDs for future generations. ? 2018 by the authors. Licensee MDPI, Basel, Switzerland. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/495214 | ISSN: | 1661-7827 | DOI: | 10.3390/ijerph15081660 | SDG/關鍵字: | 5,10 methylenetetrahydrofolate reductase (FADH2); methylenetetrahydrofolate reductase (NADPH2); MTHFR protein, human; atmospheric pollution; cardiovascular disease; cause of death; environmental factor; enzyme activity; genetic analysis; health risk; polymorphism; air pollution; Article; Brazil; China; congenital heart malformation; Egypt; ethnic difference; genetic polymorphism; Germany; homozygosity; human; Mexico; Portugal; prediction; Puerto Rico; Taiwan; Turkey (republic); air pollution; congenital heart malformation; genetic polymorphism; genetics; genotype environment interaction; meta analysis; metabolism; risk factor; Brazil; China; Egypt; Germany; Mexico [North America]; Portugal; Puerto Rico; Taiwan; Turkey; Air Pollution; Gene-Environment Interaction; Heart Defects, Congenital; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic; Risk Factors |
顯示於: | 護理學系所 |
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