|Title:||Vitamin D status and risk of metabolic syndrome among non-diabetic young adults||Authors:||Huang C.-Y.
|Issue Date:||2015||Publisher:||Churchill Livingstone||Journal Volume:||34||Journal Issue:||3||Start page/Pages:||484-489||Source:||Clinical Nutrition||Abstract:||
Background and aims: Low vitamin D status has been linked to obesity, insulin resistance, and metabolic syndrome. In the present study, we aimed to explore the nature and strength of the relationship between vitamin D and metabolic syndrome among non-diabetic young adults. Methods: This was a campus-based cross-sectional study of 355 non-diabetic young adult graduate students (233 males and 132 females; mean age, 23.5±2.4 years) in Northern Taiwan. We measured and tested the association of serum 25-hydroxyvitamin D levels with metabolic syndrome and cardio-metabolic parameters. Results: A total of 24 (6.8%) recruited young adults had metabolic syndrome. There were decreasing trends of body mass index (BMI), Homeostasis Model of Assessment-Insulin Resistance (HOMA-IR) and prevalence of metabolic syndrome across increasing tertiles of vitamin D levels irrespective of age and sex (P for trend <0.05). Without adjusting for BMI or HOMA-IR, the odds of having metabolic syndrome decreased across increasing tertiles of vitamin D levels (P for trend 0.021). The odds ratio of having metabolic syndrome was 0.26 (95% confidence interval: 0.08-0.85, P=0.025) for the highest vs. the lowest tertile of vitamin D levels. However, further adjustments for BMI and HOMA-IR largely removed the inverse association of vitamin D status with metabolic syndrome and its individual components. Conclusion: Among non-diabetic young adults, the potential inverse relationship between vitamin D status and metabolic syndrome may be attributable to the conjunctive effects of individual obesity and insulin resistance. ? 2014 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism.
|ISSN:||0261-5614||DOI:||10.1016/j.clnu.2014.05.010||SDG/Keyword:||25 hydroxyvitamin D; glucose blood level; high density lipoprotein cholesterol; low density lipoprotein cholesterol; triacylglycerol; vitamin D; adult; age distribution; Article; attributable risk; body mass; cardiovascular parameters; clinical assessment; controlled study; cross-sectional study; diabetes mellitus; female; graduate student; Homeostasis Model of Assessment Insulin Resistance; human; insulin resistance; major clinical study; male; metabolic parameters; metabolic syndrome X; obesity; prevalence; risk assessment; sex difference; Taiwan; vitamin blood level; vitamin D deficiency; young adult; blood; blood pressure; glucose blood level; insulin resistance; metabolic syndrome X; metabolism; non insulin dependent diabetes mellitus; obesity; risk factor; statistical model; vitamin D deficiency; waist circumference; Adult; Blood Glucose; Blood Pressure; Body Mass Index; Cholesterol, HDL; Cholesterol, LDL; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Female; Humans; Insulin Resistance; Linear Models; Male; Metabolic Syndrome X; Obesity; Prevalence; Risk Factors; Taiwan; Triglycerides; Vitamin D; Vitamin D Deficiency; Waist Circumference; Young Adult
|Appears in Collections:||醫學系|
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