https://scholars.lib.ntu.edu.tw/handle/123456789/495464
標題: | Higher blood aldosterone level in metabolic syndrome is independently related to adiposity and fasting plasma glucose | 作者: | Chiang J.-K. CHI-LING CHEN FEN-YU TSENG Chi Y.-C. KUO-CHIN HUANG WEI-SHIUNG YANG |
公開日期: | 2015 | 出版社: | BioMed Central Ltd. | 卷: | 14 | 期: | 1 | 起(迄)頁: | 3 | 來源出版物: | Cardiovascular Diabetology | 摘要: | Background: Hypoadiponectinemia is a well-known state associated with metabolic syndrome (MetS) and insulin resistance (IR). Recently aldosterone has been highly associated with high blood pressure, and may thus be a possible biomarker for MetS and IR. In this study, we investigate the association of aldosterone with MetS and IR, and compare it with that of adiponectin. Methods: In this cross-sectional study, we recruited 556 women receiving physical examinations at a general hospital in central Taiwan. At the time of examination, we collected data on various demographic and physical characteristics and measured blood levels of aldosterone, adiponectin and a variety of metabolic factors. Multiple linear regression analysis was performed using adiponectin or aldosterone as the dependent variables. Results: We found an inverse correlation between blood adiponectin and aldosterone (γ=-0.11, P=0.009). Adiponectin levels were lower and aldosterone levels higher in women with MetS that those without (8.1±0.4 vs. 11.5±0.2μg/mL, P<0.001 and 691±50 vs. 560±11 pmol/L, P=0.013, respectively), as they were in women with and without IR (adiponectin 10.4±0.5 vs. 11.3±0.2μg/mL, P=0.003 and aldosterone 635±31 vs. 560±11 pmol/L, P=0.022). Although aldosterone was significantly related to body fat %, fasting plasma glucose and serum creatinine levels, the relationship between adiponectin and aldosterone was not obvious after adjustment in the multivariate analysis. Conclusion: Although aldosterone was related to metabolic factors, including body fat % and fasting plasma glucose in our female subjects, the relationship between aldosterone and adiponectin remains unclear. ? 2015 Chiang et al. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84924340537&doi=10.1186%2fs12933-015-0175-6&partnerID=40&md5=c9d0821d16dea655011bf6ccadf58b62 https://scholars.lib.ntu.edu.tw/handle/123456789/495464 |
ISSN: | 1475-2840 | DOI: | 10.1186/s12933-015-0175-6 | SDG/關鍵字: | adiponectin; aldosterone; creatinine; glucose; high density lipoprotein cholesterol; low density lipoprotein cholesterol; nitrogen; triacylglycerol; uric acid; adiponectin; aldosterone; biological marker; glucose blood level; adult; age; aldosterone blood level; Article; body fat; body mass; body weight; cross-sectional study; disease association; fasting plasma glucose; female; glucose blood level; human; hypertension; insulin resistance; major clinical study; metabolic syndrome X; obesity; physical examination; protein blood level; Taiwan; urea nitrogen blood level; waist circumference; blood; deficiency; diet restriction; glucose blood level; metabolic syndrome X; metabolism; Metabolism, Inborn Errors; middle aged; obesity; physiology; Adiponectin; Adiposity; Aldosterone; Biomarkers; Blood Glucose; Cross-Sectional Studies; Fasting; Female; Humans; Metabolic Syndrome X; Metabolism, Inborn Errors; Middle Aged |
顯示於: | 醫學系 |
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