Subclinical hypothyroidism is associated with increased risk for all-cause and cardiovascular mortality in adults
Journal
Journal of the American College of Cardiology
Journal Volume
60
Journal Issue
8
Pages
730-737
Date Issued
2012
Author(s)
Abstract
This study sought to evaluate the relationship between subclinical hypothyroidism (SCH) and all-cause and cardiovascular disease (CVD) mortality. SCH may increase the risks of hypercholesterolemia and atherosclerosis. The associations between SCH and all-cause or CVD mortality are uncertain, on the basis of the results of previous studies. A baseline cohort of 115,746 participants without a history of thyroid disease, <20 years of age, was recruited in Taiwan. SCH was defined as a serum thyroid-stimulating hormone (TSH) level of 5.0 to 19.96 mIU/l with normal total thyroxine concentrations. Euthyroidism was defined as a serum TSH level of 0.47 to 4.9 mIU/l. Cox proportional hazards regression analysis was used to estimate the relative risks (RRs) of death from all-cause and CVD for adults with SCH during a 10-year follow-up period. There were 3,669 deaths during the follow-up period; 680 deaths were due to CVD. Compared with subjects with euthyroidism, after adjustment for age, sex, body mass index, diabetes, hypertension, dyslipidemia, smoking, alcohol consumption, betel nut chewing, physical activity, income, and education level, the RRs (95% confidence interval) of deaths from all-cause and CVD among subjects with SCH were 1.30 (1.02 to 1.66), and 1.68 (1.02 to 2.76), respectively. Adult Taiwanese with SCH had an increased risk for all-cause mortality and CVD death. ? 2012 American College of Cardiology Foundation.
SDGs
Other Subjects
thyrotropin; thyroxine; adult; age; alcohol consumption; article; betel nut; body mass; cardiovascular disease; cigarette smoking; cohort analysis; confidence interval; controlled study; diabetes mellitus; disease association; dyslipidemia; educational status; euthyroidism; female; follow up; human; hypertension; income; major clinical study; male; mortality; physical activity; priority journal; proportional hazards model; risk assessment; sex difference; subclinical hypothyroidism; Taiwan; thyrotropin blood level; thyroxine blood level; Adult; Age Factors; Aged; Biological Markers; Body Mass Index; Cardiovascular Diseases; Cohort Studies; Diabetes Complications; Female; Follow-Up Studies; Humans; Hyperlipidemias; Hypertension; Hypothyroidism; Male; Middle Aged; Proportional Hazards Models; Questionnaires; Research Design; Risk Factors; Sex Factors; Taiwan; Thyrotropin
Type
journal article