Interaction of ADIPOQ genetic polymorphism with blood pressure and plasma cholesterol level on the risk of coronary artery disease
Journal
Circulation Journal
Journal Volume
73
Journal Issue
10
Pages
1934-1938
Date Issued
2009
Author(s)
Abstract
Background: The protective effect of +45T>G polymorphism in the adiponectin gene (ADIPOQ) on coronary artery disease (CAD) has been demonstrated in European populations, so this study investigated the effect of +45T>G polymorphism on the risk of CAD and its interactions with other metabolic risk factors in a Chinese population. Methods and Results: The +45T>G polymorphism (rs2241766) of ADIPOQ was genotyped in 600 patients with angiographically diagnosed CAD and in 718 controls. The G allele at the +45T>G polymorphism was associated with a lower risk of CAD (odds ratio (OR), 0.76; 95% confidence interval (CI), 0.64-0.89; P=0.001). The protective effect of the G allele at +45T>G polymorphism was magnified at blood pressure <140/90 mmHg (OR, 0.65; 95%CI, 0.51-0.82; P=0.0004), but disappeared at blood pressure ?140/90 mmHg (OR, 0.98; 95%CI, 0.76-1.28; P=0.93), indicating an interaction between +45T>G polymorphism and blood pressure on CAD risk (P=0.02 for interaction). A similar interaction was also observed between plasma cholesterol level and the +45T>G polymorphism. Conclusions: An association of ADIPOQ genetic polymorphism with CAD risk is modified by traditional risk factors, such as blood pressure and plasma cholesterol level.
SDGs
Other Subjects
cholesterol; adipoq gene; adult; allele; article; blood pressure; cardiovascular risk; Chinese; cholesterol blood level; controlled study; coronary artery disease; female; gene; genetic risk; genotype; human; major clinical study; male; risk assessment; risk factor; single nucleotide polymorphism; Adiponectin; Adult; Aged; Asian Continental Ancestry Group; Biological Markers; Blood Pressure; Case-Control Studies; China; Cholesterol; Coronary Artery Disease; Female; Gene Frequency; Genetic Predisposition to Disease; Humans; Logistic Models; Male; Middle Aged; Odds Ratio; Phenotype; Polymorphism, Single Nucleotide; Risk Assessment; Risk Factors; Taiwan
Type
journal article