https://scholars.lib.ntu.edu.tw/handle/123456789/495569
標題: | An autosomal genome-wide scan for loci linked to fre-diabetic phenotypes in nondiabetic Chinese subjects from the stanford asia-pacific program of hypertension and insulin resistance family Study | 作者: | Chiu Y.-F. LEE-MING CHUANG Hsiao C.-F. Hung Y.-J. Lin M.-W. Chen Y.-T. Grove J. Jorgenson E. Quertermous T. Risch N. Hsiung C.A. |
公開日期: | 2005 | 卷: | 54 | 期: | 4 | 起(迄)頁: | 1200-1206 | 來源出版物: | Diabetes | 摘要: | Type 2 diabetes is a complex disease involving both genetic and environmental components. Abnormalities in insulin secretion and insulin action usually precede the development of type 2 diabetes and can serve as good quantitative measures for genetic mapping. We therefore undertook an autosomal genomic search to locate the quantitative trait locus (QTL) linked to these traits in 1,365 nondiabetic Chinese subjects from 411 nuclear families. Residuals of these log-transformed quantitative traits were analyzed in multipoint linkage analysis using a variance-components approach. The most significant QTL for fasting insulin, which coincides with the QTL for homeostasis model assessment of insulin resistance, was located at 37 cM on chromosome 20, with a maximum empirical logarithm of odds (LOD) score of 3.01 (empirical P = 0.00006) when adjusted for age, sex, BMI, antihypertensive medications, recruitment centers, and environmental factors. In the same region, a QTL for fasting glucose was identified at 51 cM, with an empirical LOD score of 2.03 (empirical P = 0.0012). There were other loci with maximum empirical LOD scores ?1.29 located on chromosomes 1q, 2p, 5q, 7p, 9q, 10p, 14q, 18q, and 19q for different diabetes-related traits. These loci may harbor genes that regulate glucose homeostasis either independently or via interactions of the genes within these regions. ? 2005 by the American Diabetes Association. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-20144389452&doi=10.2337%2fdiabetes.54.4.1200&partnerID=40&md5=a5a7477182816826dffa9ebcdcf5e60d https://scholars.lib.ntu.edu.tw/handle/123456789/495569 |
ISSN: | 0012-1797 | DOI: | 10.2337/diabetes.54.4.1200 | SDG/關鍵字: | antihypertensive agent; genomic DNA; glucose; insulin; adult; age; alcohol consumption; article; body mass; Chinese; chromosome 10p; chromosome 14q; chromosome 18q; chromosome 19q; chromosome 1q; chromosome 20; chromosome 2p; cigarette smoking; controlled study; environmental factor; family study; female; genetic linkage; genetic susceptibility; genome; glucose blood level; glucose homeostasis; human; hypertension; insulin blood level; insulin resistance; major clinical study; male; non insulin dependent diabetes mellitus; phenotype; physical activity; priority journal; quantitative trait locus; sex difference; Asian Continental Ancestry Group; Diabetes Mellitus, Type 2; Female; Genetic Predisposition to Disease; Genome, Human; Genotype; Hawaii; Humans; Insulin; Linkage (Genetics); Male; Phenotype; Prediabetic State; Quantitative Trait Loci; Risk Factors; San Francisco; Taiwan |
顯示於: | 醫學系 |
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