Surrogate estimates of insulin sensitivity in subjects with hypertension
Journal
Journal of Human Hypertension
Journal Volume
21
Journal Issue
3
Pages
246-252
Date Issued
2007
Author(s)
Hwu C.-M.
Hsiao C.F.
Grove J.
Hung Y.J.
Chen Y.T.
Curb J.D.
Chen Y.D.I.
Rodriguez B.
Ho L.T.
Abstract
The purpose of the study is to compare surrogate estimates of insulin sensitivity with a directly measured insulin sensitivity index, steady-state plasma glucose (SSPG) from insulin suppression test (IST), in subjects with hypertension. Two hundred and twenty-eight hypertensive patients who received IST for SSPG were included for analysis. Estimates from fasting measurements alone, homeostasis model assessment for insulin resistance (HOMA-IR) and quantitative insulin sensitivity check index (QUICKI)), and indices from fasting and/or 2h samples (ISI0,120 and ISITX) were calculated. In addition to Pearson and partial correlations, variance-component models were used to test the relationship between surrogate estimates of insulin sensitivity and SSPG. A large proportion of variance owing to covariates in the variance-component models indicated the goodness of model fit, irrespective of the independence among variables. SSPG was positively correlated with logarithmic transformation (Log) (HOMA-IR) and negatively correlated with QUICKI, Log (ISI0,120) and ISITX (all P<0.0001). Log (ISI0,120) seemed to have a better correlation with SSPG (r=-0.72) than other measures in partial correlation. The proportion of variance owing to all covariates of Log (ISI0,120) and ISITX were larger than those of Log (HOMA-IR) and QUICKI in the variance-component models. After adjustments for demographic and obesity covariates, the proportion of variance explained by Log (ISI0,120) were largest among the surrogate measures in the variance-component models. Our results showed that ISI0,120 and ISITX correlated better with SSPG than those used fasting measures alone (HOMA-IR and QUICKI). Log (ISI0,120) currently showing the strongest association with SSPG than other estimates is adaptable for use in large studies of hypertension.
SDGs
Other Subjects
angiotensin receptor antagonist; beta adrenergic receptor blocking agent; calcium channel blocking agent; dipeptidyl carboxypeptidase inhibitor; diuretic agent; glucose; hydroxymethylglutaryl coenzyme A reductase inhibitor; insulin; isophane insulin; somatosan; somatostatin; taiyu; unclassified drug; adult; article; correlation coefficient; diabetes mellitus; diet restriction; female; glucose assay; glucose homeostasis; human; hypertension; impaired glucose tolerance; insulin infusion; insulin pump; insulin resistance; insulin sensitivity; insulin tolerance test; intermethod comparison; major clinical study; male; Adult; Analysis of Variance; Asian Continental Ancestry Group; Blood Glucose; Diabetes Mellitus; Female; Glucose Clamp Technique; Humans; Hypertension; Insulin; Insulin Resistance; Male; Middle Aged; Predictive Value of Tests; Sensitivity and Specificity
Type
journal article