|Title:||Assessment of blood glucose regulation and safety of resistant starch formula-based diet in healthy normal and subjects with type 2 diabetes||Authors:||Lin C.-H.
|Issue Date:||2015||Publisher:||Lippincott Williams and Wilkins||Journal Volume:||94||Journal Issue:||33||Start page/Pages:||e1332||Source:||Medicine (United States)||Abstract:||
To evaluate the effects of the new resistant starch (RS) formula, PPB-R-203, on glucose homeostasis in healthy subjects and subjects with type 2 diabetes. A cohort consisting of 40 healthy participants received test and control diets and was checked for up to 3 hours post-meal. A randomized, 2-regimen, cross-over, comparative study was conducted in 44 subjects with type 2 diabetes and glycemic control was assessed with a continuous glucose monitoring system. In healthy participants, serum glucose values and incremental areas under the glucose curves (AUC) were significantly lower in the PPB-R-203 than the control group (P<0.05). In patients with type 2 diabetes, mean blood glucose concentrations for subjects on the control regimen were higher than those for subjects on the PPB-R-203-based regimen (7.9±1.7, 95% confidence interval [CI] 7.4-8.4 vs 7.4±1.6, 95% CI 6.9-7.9mmol/L, respectively; P=0.023). AUCs for total blood glucose and hyperglycemia (glucose >10mmol/L) were also reduced for subjects on the PPB-R-203-based regimen as compared with those on control regimen (total blood glucose: 16.2±4.0, 95% CI 14.9-17.4 vs 18.7±4.0, 95% CI 17.6-20.1, P<0.001; hyperglycemia: 4.9±5.7, 95% CI 3.1-6.6 vs 6.3±6.4, 95% CI 4.3-8.3mmol/L × day, P=0.021). However, AUC measurements for hypoglycemia (glucose <3.9mmol/l) were not statistically significant. A PPB-R-203-based diet reduced postprandial hyperglycemia in patients with type 2 diabetes without increasing the risk of hypoglycemia or glucose excursion. ? 2015 Wolters Kluwer Health, Inc.
|ISSN:||0025-7974||DOI:||10.1097/MD.0000000000001332||SDG/Keyword:||2,4 thiazolidinedione derivative; acarbose; glucose; insulin; metformin; starch; sulfonylurea; antidiabetic agent; glucose blood level; insulin; starch; adult; aged; area under the curve; Article; blood glucose monitoring; clinical article; cohort analysis; comparative study; controlled study; crossover procedure; diet therapy; female; food intake; glucose blood level; glucose homeostasis; glycemic control; glycemic index; human; hyperglycemia; hypoglycemia; insulin response; insulin treatment; male; meal; non insulin dependent diabetes mellitus; postprandial state; priority journal; randomized controlled trial; resistant starch formula based diet; analysis; blood; Diabetes Mellitus, Type 2; diabetic diet; hyperglycemia; middle aged; procedures; treatment outcome; Adult; Area Under Curve; Blood Glucose; Cross-Over Studies; Diabetes Mellitus, Type 2; Diet, Diabetic; Female; Humans; Hyperglycemia; Hypoglycemic Agents; Insulin; Male; Middle Aged; Starch; Treatment Outcome
|Appears in Collections:||醫學系|
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