Assessment of blood glucose regulation and safety of resistant starch formula-based diet in healthy normal and subjects with type 2 diabetes

To evaluate the effects of the new resistant starch (RS) formula, PPB-R-203, on glucose homeostasis in healthy subjects and subjects with type 2 diabetes. A cohort consisting of 40 healthy participants received test and control diets and was checked for up to 3 hours post-meal. A randomized, 2-regimen, cross-over, comparative study was conducted in 44 subjects with type 2 diabetes and glycemic control was assessed with a continuous glucose monitoring system. In healthy participants, serum glucose values and incremental areas under the glucose curves (AUC) were significantly lower in the PPB-R-203 than the control group (P<0.05). In patients with type 2 diabetes, mean blood glucose concentrations for subjects on the control regimen were higher than those for subjects on the PPB-R-203-based regimen (7.9±1.7, 95% confidence interval [CI] 7.4-8.4 vs 7.4±1.6, 95% CI 6.9-7.9mmol/L, respectively; P=0.023). AUCs for total blood glucose and hyperglycemia (glucose >10mmol/L) were also reduced for subjects on the PPB-R-203-based regimen as compared with those on control regimen (total blood glucose: 16.2±4.0, 95% CI 14.9-17.4 vs 18.7±4.0, 95% CI 17.6-20.1, P<0.001; hyperglycemia: 4.9±5.7, 95% CI 3.1-6.6 vs 6.3±6.4, 95% CI 4.3-8.3mmol/L × day, P=0.021). However, AUC measurements for hypoglycemia (glucose <3.9mmol/l) were not statistically significant. A PPB-R-203-based diet reduced postprandial hyperglycemia in patients with type 2 diabetes without increasing the risk of hypoglycemia or glucose excursion. ? 2015 Wolters Kluwer Health, Inc.