https://scholars.lib.ntu.edu.tw/handle/123456789/495760
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Lin C.-H. | en_US |
dc.contributor.author | Chang D.-M. | en_US |
dc.contributor.author | Wu D.-J. | en_US |
dc.contributor.author | Peng H.-Y. | en_US |
dc.contributor.author | LEE-MING CHUANG | en_US |
dc.creator | LEE-MING CHUANG;Peng H.-Y.;Wu D.-J.;Chang D.-M.;Lin C.-H. | - |
dc.date.accessioned | 2020-06-01T04:31:28Z | - |
dc.date.available | 2020-06-01T04:31:28Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 0025-7974 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84943174795&doi=10.1097%2fMD.0000000000001332&partnerID=40&md5=3ef1a10043a2b3ba9eb457b589ff911d | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/495760 | - |
dc.description.abstract | To evaluate the effects of the new resistant starch (RS) formula, PPB-R-203, on glucose homeostasis in healthy subjects and subjects with type 2 diabetes. A cohort consisting of 40 healthy participants received test and control diets and was checked for up to 3 hours post-meal. A randomized, 2-regimen, cross-over, comparative study was conducted in 44 subjects with type 2 diabetes and glycemic control was assessed with a continuous glucose monitoring system. In healthy participants, serum glucose values and incremental areas under the glucose curves (AUC) were significantly lower in the PPB-R-203 than the control group (P<0.05). In patients with type 2 diabetes, mean blood glucose concentrations for subjects on the control regimen were higher than those for subjects on the PPB-R-203-based regimen (7.9±1.7, 95% confidence interval [CI] 7.4-8.4 vs 7.4±1.6, 95% CI 6.9-7.9mmol/L, respectively; P=0.023). AUCs for total blood glucose and hyperglycemia (glucose >10mmol/L) were also reduced for subjects on the PPB-R-203-based regimen as compared with those on control regimen (total blood glucose: 16.2±4.0, 95% CI 14.9-17.4 vs 18.7±4.0, 95% CI 17.6-20.1, P<0.001; hyperglycemia: 4.9±5.7, 95% CI 3.1-6.6 vs 6.3±6.4, 95% CI 4.3-8.3mmol/L × day, P=0.021). However, AUC measurements for hypoglycemia (glucose <3.9mmol/l) were not statistically significant. A PPB-R-203-based diet reduced postprandial hyperglycemia in patients with type 2 diabetes without increasing the risk of hypoglycemia or glucose excursion. ? 2015 Wolters Kluwer Health, Inc. | - |
dc.publisher | Lippincott Williams and Wilkins | - |
dc.relation.ispartof | Medicine (United States) | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | 2,4 thiazolidinedione derivative; acarbose; glucose; insulin; metformin; starch; sulfonylurea; antidiabetic agent; glucose blood level; insulin; starch; adult; aged; area under the curve; Article; blood glucose monitoring; clinical article; cohort analysis; comparative study; controlled study; crossover procedure; diet therapy; female; food intake; glucose blood level; glucose homeostasis; glycemic control; glycemic index; human; hyperglycemia; hypoglycemia; insulin response; insulin treatment; male; meal; non insulin dependent diabetes mellitus; postprandial state; priority journal; randomized controlled trial; resistant starch formula based diet; analysis; blood; Diabetes Mellitus, Type 2; diabetic diet; hyperglycemia; middle aged; procedures; treatment outcome; Adult; Area Under Curve; Blood Glucose; Cross-Over Studies; Diabetes Mellitus, Type 2; Diet, Diabetic; Female; Humans; Hyperglycemia; Hypoglycemic Agents; Insulin; Male; Middle Aged; Starch; Treatment Outcome | - |
dc.title | Assessment of blood glucose regulation and safety of resistant starch formula-based diet in healthy normal and subjects with type 2 diabetes | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1097/MD.0000000000001332 | - |
dc.identifier.pmid | 26287417 | - |
dc.identifier.scopus | 2-s2.0-84943174795 | - |
dc.relation.pages | e1332 | - |
dc.relation.journalvolume | 94 | - |
dc.relation.journalissue | 33 | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.orcid | 0000-0003-0978-2662 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 醫學系 |
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