A triglyceride-raising APOA5 genetic variant is negatively associated with obesity and BMI in the Chinese population
Journal
Obesity
Journal Volume
18
Journal Issue
10
Pages
1964-1968
Date Issued
2010
Author(s)
Hua S.-C.
Wu H.-Y.
Lee W.-J.
Lien W.-P.
Abstract
Apolipoprotein A-V (apo A-V) exerts a potent triglyceride (TG)-lowering effect through enhanced intravascular TG-hydrolysis with increased uptake of TG-derived free fatty acids into muscle and adipose tissue. Genetic variants in the APOA5 gene were strongly associated with plasma TG concentrations. The aim of this study was to examine whether APOA5 genetic variation was associated with obesity. We genotyped the missense c.553 G>T polymorphism (p.G185C) in the APOA5 gene in 1,085 Chinese (333 obese subjects and 752 nonobese controls). We analyzed the association between the c.553G>T polymorphism and obesity and related metabolic phenotypes. The T allele at the c.553G>T polymorphism was associated with higher plasma TG concentrations. Each additional T allele was associated with an increased TG concentration of 53.5mg/dl (95% confidence interval (CI) 29.6-76.0, P < 0.0001). However, the T allele was associated lower risk of obesity (odds ratio (OR), 0.48; 95% CI 0.32-0.73, P = 0.0004). Each additional copy of the T allele was associated with a BMI decrease of 0.73kg/m2 (95% CI 0.26-1.16, P = 0.002), equivalent to 2.11kg in a person 1.7m tall. We may then conclude that the TG-raising APOA5 genetic variant was associated with a decrease in BMI and reduced risk of obesity in the Chinese population. ? 2010 The Obesity Society.
SDGs
Other Subjects
APOA5 protein, human; apolipoprotein A; triacylglycerol; adult; aged; allele; article; Asian; blood; body mass; ethnology; female; genetic polymorphism; genetics; genotype; human; male; middle aged; obesity; risk; risk factor; Adult; Aged; Alleles; Apolipoproteins A; Asian Continental Ancestry Group; Body Mass Index; Female; Genotype; Humans; Male; Middle Aged; Obesity; Odds Ratio; Polymorphism, Genetic; Risk Factors; Triglycerides; Young Adult
Type
journal article