https://scholars.lib.ntu.edu.tw/handle/123456789/495791
標題: | Association of paraoxonase 1 polymorphism with β-cell function: A case of molecular heterosis | 作者: | Chiu K.C. LEE-MING CHUANG Chu A. Lu J. Hu J. Fernando S. |
關鍵字: | Diabetes; Insulin secretion; Molecular heterosis; Paraoxonase; Polymorphism; β-cell function | 公開日期: | 2004 | 卷: | 28 | 期: | 4 | 起(迄)頁: | e96-e103 | 來源出版物: | Pancreas | 摘要: | Paraoxonase 1 (PON1) is an antioxidant enzyme that inhibits the oxidative modification of LDL. Since PON1 has been shown to express in pancreatic islets and oxidative stress plays a role in β-cell dysfunction, we investigated the impact of the PON1 polymorphisms on β-cell function. This study included 84 healthy and glucose-tolerant white subjects who underwent an oral glucose tolerance test. β-cell function (1stPHSand 2ndPHS) was estimated according to the formulae published by Stumvoll et al. The relationship of the L55M and Q192R polymorphisms to β-cell function was examined. Allelic frequency in this population was 0.37 for the M allele and 0.30 for the R allele. For the L55M polymorphism, the LM genotype had the lowest 1stPHS (P = 0.009) and 2ndPHS (P = 0.007), indicating molecular heterosis. Multivariate analyses confirmed that the L55M polymorphism was an independent determinant for 1stPHS(P = 0.016) and 2ndPHS(P = 0.009), after adjustment for covariates. For the Q192M polymorphism, no difference was noted in 1stPHSand 2ndPHS. We observed the L55M polymorphism of the PON1 gene as an independent determinant for β-cell function in glucose-tolerant whites. Our observations suggest that this polymorphism could play a role in β-cell dysfunction. ? 2004 Lippincott Williams and Wilkins, Inc. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-2942651128&doi=10.1097%2f00006676-200405000-00021&partnerID=40&md5=43a479de2fbde1dcc21e064ce544972f https://scholars.lib.ntu.edu.tw/handle/123456789/495791 |
ISSN: | 0885-3177 | DOI: | 10.1097/00006676-200405000-00021 | SDG/關鍵字: | aryldialkylphosphatase; insulin; adult; article; blood; female; gene frequency; genetic polymorphism; genetics; glucose tolerance test; heterosis; human; male; pancreas islet; physiology; Adult; Aryldialkylphosphatase; Female; Gene Frequency; Glucose Tolerance Test; Humans; Hybrid Vigor; Insulin; Islets of Langerhans; Male; Polymorphism, Genetic |
顯示於: | 醫學系 |
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