https://scholars.lib.ntu.edu.tw/handle/123456789/496048
標題: | Metformin and the risk of dementia in type 2 diabetes patients | 作者: | CHIN-HSIAO TSENG | 關鍵字: | Dementia; Diabetes mellitus; Metformin; Taiwan | 公開日期: | 2019 | 出版社: | International Society on Aging and Disease | 卷: | 10 | 期: | 1 | 起(迄)頁: | 37-48 | 來源出版物: | Aging and Disease | 摘要: | This retrospective cohort study investigated dementia risk associated with metformin use in type 2 diabetes patients by using the reimbursement database of the Taiwan’s National Health Insurance. The patients had new-onset diabetes during 1999-2005 and were followed up until December 31, 2011. An unmatched cohort of 147,729 ever users and 15,676 never users of metformin were identified, and a matched-pair cohort of 15,676 ever users and 15,676 never users was created by propensity score (PS). Hazard ratios were estimated by Cox regression incorporated with the inverse probability of treatment weighting using PS. Results showed that in the unmatched cohort, 713 never users and 3943 ever users developed dementia with respective incidence of 1029.20 and 570.03 per 100,000 person-years. The overall hazard ratio was 0.550 (95% confidence interval: 0.508-0.596). The hazard ratio for the first (<27.0 months), second (27.0-58.1 months) and third (>58.1 months) tertile of cumulative duration of metformin therapy was 0.975 (0.893-1.066), 0.554 (0.506-0.607) and 0.286 (0.259-0.315), respectively. Analyses in the matched cohort showed an overall hazard ratio of 0.707 (0.632-0.791) and the hazard ratio for the respective tertile was 1.279 (1.100-1.488), 0.704 (0.598-0.829) and 0.387 (0.320-0.468). In conclusion, metformin use is associated with a reduced dementia risk. ? 2017 Tseng CH. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85065771673&doi=10.14336%2fAD.2017.1202&partnerID=40&md5=5e7220827309de19d9ce4ae4cf1d8812 https://scholars.lib.ntu.edu.tw/handle/123456789/496048 |
ISSN: | 2152-5250 | DOI: | 10.14336/AD.2017.1202 | SDG/關鍵字: | acarbose; dipeptidyl carboxypeptidase inhibitor; incretin; insulin; meglitinide; metformin; sulfonylurea; adult; algorithm; Article; chronic obstructive lung disease; cohort analysis; dementia; diagnostic error; drug exposure; female; hazard ratio; health care system; human; ICD-9-CM; male; middle aged; national health insurance; non insulin dependent diabetes mellitus; propensity score; retrospective study; sensitivity analysis |
顯示於: | 醫學系 |
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