https://scholars.lib.ntu.edu.tw/handle/123456789/496076
標題: | Type 2 diabetes mellitus and kidney cancer risk: A retrospective cohort analysis of the National Health Insurance | 作者: | CHIN-HSIAO TSENG | 公開日期: | 2015 | 出版社: | Public Library of Science | 卷: | 10 | 期: | 11 | 起(迄)頁: | e0142480 | 來源出版物: | PLoS ONE | 摘要: | Purpose: To evaluate the association between incidence of any kidney cancer and type 2 diabetes mellitus. Methods: A random sample of 1,000,000 subjects covered by the National Health Insurance was recruited. A total of 998728 people (115655 diabetes and 883073 non-diabetes) without kidney cancer at recruitment were followed from 2003 to 2005. The cumulative incidence of kidney cancer from 2003 to 2005 in diabetic patients and non-diabetic people in all ages and in age <40, 40-64, 65-74 and >75 years were calculated in the diabetic patients and the non-diabetic people, respectively. Logistic regression was used to estimate the odds ratios comparing diabetic patients to non-diabetic people in the respective age groups. Multivariable-adjusted odds ratios for kidney cancer with regards to diabetes status and diabetes duration (as a continuous variable or categorized into subgroups of non-diabetes, diabetes duration <1 year, 1-2.9 years, 3-4.9 years and >5 years) were estimated after multivariable adjustment. The multivariable-adjusted odds ratios for all baseline variables were also estimated for diabetic patients and non-diabetic people, respectively. Results: The 3-year cumulative incidence of kidney cancer in the diabetic patients and the non-diabetic people was 166.9 and 33.1 per 100,000 person-years, respectively. The incidence increased with regards to increasing age in both the diabetic patients and the non-diabetic people, but a higher risk of kidney cancer for the diabetic patients compared to the non-diabetic people was consistently observed in different age groups. After multivariable adjustment, the odds ratio for diabetic patients versus non-diabetic people was 1.7 (95% confidence interval: 1.3-2.1, P<0.01). While compared to the non-diabetic people, the odds ratio (95% confidence interval) for diabetes duration <1,1-2.9 years, 3-4.9 years and >5 years was 1.5 (0.8-2.7), 1.6 (1.0-2.4), 1.6 (1.1-2.4) and 1.7 (1.3-2.3), respectively (P-trend <0.01). Analyses conducted in the diabetic patients and the non-diabetic people, respectively, consistently showed age, nephropathy and end-stage renal disease as significant risk factors of kidney cancer. Additionally, living in metropolitan Taipei region might also be associated with a higher risk of kidney cancer in the non-diabetic people, indicating a potential link between kidney cancer and some factors related to urbanization. Conclusions: Patients with type 2 diabetes mellitus have a significantly higher risk of kidney cancer. © 2015 Chin-Hsiao Tseng.This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84955475058&doi=10.1371%2fjournal.pone.0142480&partnerID=40&md5=e790e29f8c6af5912a9f85f8dd10b5b1 https://scholars.lib.ntu.edu.tw/handle/123456789/496076 |
ISSN: | 1932-6203 | DOI: | 10.1371/journal.pone.0142480 | SDG/關鍵字: | adult; age; aged; Article; cancer incidence; cancer risk; Chinese; cohort analysis; controlled study; disease association; disease duration; end stage renal disease; female; human; kidney cancer; logistic regression analysis; major clinical study; male; national health insurance; non insulin dependent diabetes mellitus; retrospective study; risk factor; Taiwan; complication; Diabetes Mellitus, Type 2; incidence; Kidney Neoplasms; middle aged; odds ratio; public health; statistical model; Adult; Aged; Cohort Studies; Diabetes Mellitus, Type 2; Female; Humans; Incidence; Kidney Neoplasms; Logistic Models; Male; Middle Aged; National Health Programs; Odds Ratio; Retrospective Studies; Risk Factors; Taiwan |
顯示於: | 醫學系 |
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