https://scholars.lib.ntu.edu.tw/handle/123456789/496094
標題: | Metformin may reduce breast cancer risk in Taiwanese women with type 2 diabetes | 作者: | CHIN-HSIAO TSENG | 公開日期: | 2014 | 出版社: | Springer New York LLC | 卷: | 145 | 期: | 3 | 起(迄)頁: | 785-790 | 來源出版物: | Breast Cancer Research and Treatment | 摘要: | Whether metformin therapy affects breast cancer risk in Asian patients with type 2 diabetes mellitus (T2DM) has not been investigated. The reimbursement databases of Taiwanese female patients with a new diagnosis of T2DM between 1998 and 2002 (n = 476,282) were retrieved from the National Health Insurance for follow-up of breast cancer until the end of 2009. Metformin was treated as a time-dependent variable; and of these patients, 285,087 were never-users and 191,195 were ever-users. A time-dependent approach was used to calculate breast cancer incidence and estimate hazard ratios by Cox regression for ever-users, never-users, and subgroups of metformin exposure (tertiles of cumulative duration and cumulative dose). During follow-up, 2,412 (1.26 %) metformin ever-users and 9,322 (2.10 %) never-users developed breast cancer, representing an incidence of 201.08 and 535.88 per 100,000 person-years, respectively. The overall multivariable-adjusted hazard ratio (95 % confidence intervals) for ever- versus never-users was 0.630 (0.597-0.665). The multivariable-adjusted hazard ratios for the first, second, and third tertiles of cumulative duration of metformin therapy were 1.122 (1.043-1.207), 0.754 (0.692-0.820), and 0.280 (0.253-0.310), respectively, (P-trend <0.0001); and 1.099 (1.021-1.182), 0.664 (0.611-0.723), and 0.311 (0.281-0.344), respectively, (P-trend <0.0001), for cumulative dose of metformin. Metformin use is associated with a decreased risk of breast cancer. ? 2014 Springer Science+Business Media New York. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84901623124&doi=10.1007%2fs10549-014-2985-8&partnerID=40&md5=c9deab0e4963efc4fa78084edc7b42d9 https://scholars.lib.ntu.edu.tw/handle/123456789/496094 |
ISSN: | 0167-6806 | DOI: | 10.1007/s10549-014-2985-8 | SDG/關鍵字: | metformin; antidiabetic agent; metformin; adult; article; breast cancer; cancer incidence; cancer risk; controlled study; female; follow up; human; major clinical study; non insulin dependent diabetes mellitus; obesity; priority journal; risk reduction; Taiwan; Breast Neoplasms; complication; epidemiology; middle aged; non insulin dependent diabetes mellitus; Breast Neoplasms; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agents; Metformin; Middle Aged; Taiwan |
顯示於: | 醫學系 |
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