https://scholars.lib.ntu.edu.tw/handle/123456789/496116
標題: | Diabetes, insulin use, and gastric cancer: A population-based analysis of the taiwanese | 作者: | CHIN-HSIAO TSENG | 公開日期: | 2013 | 卷: | 47 | 期: | 6 | 起(迄)頁: | e60-e64 | 來源出版物: | Journal of Clinical Gastroenterology | 摘要: | The association between diabetes and gastric cancer is rarely studied, and the risk associated with insulin use is not known. Gastric cancer prevalence rates in 2005 were calculated in 329,198 insurants aged 45 years or older and without type 1 diabetes from a random sample of 1,000,000 insurants of the National Health Insurance in Taiwan. Logistic regression evaluated whether diabetes or insulin use could be an independent risk factor after adjustment for age, sex, occupation, and living region. Sensitivity analyses were performed by excluding patients with diabetes duration <5 years and by excluding patients with cancers other than gastric cancer. A total of 1464 cases of gastric cancer were identified. The prevalence of gastric cancer in diabetic and nondiabetic subjects were 595.0 and 387.7 per 100,000 population (P<0.0001), respectively. In diabetic patients, the respective prevalence of gastric cancer in insulin users and nonusers were 656.0 and 589.5 (P=0.4743). Adjusted odds ratio for diabetic versus nondiabetic subjects was 1.139 (1.022 to 1.270), and for insulin users versus nonusers in the diabetic patients was 1.002 (0.745 to 1.346). Age and male sex were also associated with significantly higher risk of gastric cancer, but the association with occupation and living region were not consistent. Results from sensitivity analyses were similar. Diabetic patients may have a 14% higher risk of gastric cancer. However, insulin use is not related to the increased risk. ? 2013 Lippincott Williams & Wilkins, Inc. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84879890089&doi=10.1097%2fMCG.0b013e31827245eb&partnerID=40&md5=b9ccaf5f420f9eec57d971014829a5fb https://scholars.lib.ntu.edu.tw/handle/123456789/496116 |
ISSN: | 0192-0790 | DOI: | 10.1097/MCG.0b013e31827245eb | SDG/關鍵字: | insulin; adult; aged; article; cancer patient; diabetes mellitus; diabetic patient; female; human; major clinical study; male; national health insurance; occupation; prevalence; priority journal; reimbursement; stomach cancer; Taiwan; Aged; Diabetes Complications; Diabetes Mellitus, Type 2; Female; Humans; Insulin; Male; Middle Aged; Prevalence; Risk Assessment; Stomach Neoplasms; Taiwan |
顯示於: | 醫學系 |
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