https://scholars.lib.ntu.edu.tw/handle/123456789/496121
標題: | Evaluation of the association between arsenic and diabetes: A National Toxicology Program workshop review | 作者: | Maull E.A. Ahsan H. Edwards J. Longnecker M.P. Navas-Acien A. Pi J. Silbergeld E.K. Styblo M. CHIN-HSIAO TSENG Thayer K.A. Loomis D. |
公開日期: | 2012 | 卷: | 120 | 期: | 12 | 起(迄)頁: | 1658-1670 | 來源出版物: | Environmental Health Perspectives | 摘要: | Background: Diabetes affects an estimated 346 million persons globally, and total deaths from diabetes are projected to increase >50% in the next decade. Understanding the role of environmental chemicals in the development or progression of diabetes is an emerging issue in environmental health. In 2011, the National Toxicology Program (NTP) organized a workshop to assess the literature for evidence of associations between certain chemicals, including inorganic arsenic, and diabetes and/or obesity to help develop a focused research agenda. This review is derived from discussions at that workshop. Objectives: Our objectives were to assess the consistency, strength/weaknesses, and biological plausibility of findings in the scientific literature regarding arsenic and diabetes and to identify data gaps and areas for future evaluation or research. The extent of the existing literature was insufficient to consider obesity as an outcome. Data Sources, Extraction, and Synthesis: Studies related to arsenic and diabetes or obesity were identified through PubMed and supplemented with relevant studies identified by reviewing the reference lists in the primary literature or review articles. Conclusions: Existing human data provide limited to sufficient support for an association between arsenic and diabetes in populations with relatively high exposure levels (?150μg arsenic/L in drinking water). The evidence is insufficient to conclude that arsenic is associated with diabetes in lower exposure (<150μg arsenic/L drinking water), although recent studies with better measures of outcome and exposure support an association. The animal literature as a whole was inconclusive; however, studies using better measures of diabetes-relevant end points support a link between arsenic and diabetes. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84864884168&doi=10.1289%2fehp.1104579&partnerID=40&md5=56ca0d833a328a22eefdd1b8bad5a0fb https://scholars.lib.ntu.edu.tw/handle/123456789/496121 |
ISSN: | 0091-6765 | DOI: | 10.1289/ehp.1104579 | SDG/關鍵字: | arsenic; drinking water; arsenic poisoning; diabetes mellitus; disease association; disease course; environmental exposure; glucose blood level; health program; human; insulin release; kidney concentrating capacity; mortality; nonhuman; pancreas islet beta cell; priority journal; review; risk factor; scientific literature; sea food; Animals; Arsenic; Diabetes Mellitus; Drinking Water; Environmental Exposure; Humans; Mice; Obesity; Rats; Water Pollutants, Chemical; Animalia |
顯示於: | 醫學系 |
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