Differential dyslipidemia associated with albuminuria in type 2 diabetic patients in Taiwan
Journal
Clinical Biochemistry
Journal Volume
42
Journal Issue
44115
Pages
1019-1024
Date Issued
2009
Author(s)
Abstract
Background: This study evaluated the lipid abnormalities associated with different stages of albuminuria in type 2 diabetic patients. Methods and results: A total of 549 patients (245 men and 304 women) with mean age of 63.4 were studied. Normoalbuminuria (n = 251), microalbuminuria (n = 242) and macroalbuminuria (n = 56) were defined as albumin-to-creatinine ratio of < 30, 30-299 and ? 300?μg/mg, respectively. Lipid parameters included total cholesterol, triglyceride (TG), high- and low-density lipoprotein (LDL) cholesterol, apolipoproteins A1 and B (ApoB), and lipoprotein(a) [Lp(a)]. Results showed that ApoB differed significantly (p < 0.05) between normoalbuminuria and microalbuminuria/macroalbuminuria and Ln[Lp(a)] differed between normoalbuminuria/microalbuminuria and macroalbuminuria. Ln(TG) increased progressively with increasing albuminuria. In multivariate logistic regression analyses, only ApoB showed significant odds ratio (95% confidence interval) for microalbuminuria: 1.013 (1.004-1.022); and both ln(TG) and ln[Lp(a)] were significant for macroalbuminuria [respective odds ratios: 1.995 (1.010-3.938) and 1.708 (1.200-2.430)]. Conclusions: A differential dyslipidemia is observed for microalbuminuria and macroalbuminuria. Apo(B) and Lp(a) increase at the stages of microalbuminuria and macroalbuminuria, respectively. However, TG increases significantly throughout the three stages of albuminuria. ? 2009 The Canadian Society of Clinical Chemists.
SDGs
Other Subjects
angiotensin receptor antagonist; apolipoprotein A1; apolipoprotein B; cholesterol; dipeptidyl carboxypeptidase inhibitor; fibric acid derivative; high density lipoprotein cholesterol; hydroxymethylglutaryl coenzyme A reductase inhibitor; insulin; lipoprotein; low density lipoprotein cholesterol; oral antidiabetic agent; triacylglycerol; adult; albumin blood level; albuminuria; article; cholesterol blood level; cohort analysis; controlled study; creatinine blood level; creatinine urine level; cross-sectional study; diabetic nephropathy; disease association; disease severity; dyslipidemia; female; follow up; human; hypertension; longitudinal study; major clinical study; male; microalbuminuria; non insulin dependent diabetes mellitus; priority journal; protein blood level; Taiwan; triacylglycerol blood level; urine level; Albuminuria; Asian Continental Ancestry Group; Diabetes Mellitus, Type 2; Dyslipidemias; Female; Humans; Lipids; Male; Middle Aged; Odds Ratio; Taiwan
Type
journal article