https://scholars.lib.ntu.edu.tw/handle/123456789/496176
標題: | Effect of parental hypertension and/or parental diabetes on hypertension in Taiwanese diabetic patients | 作者: | CHIN-HSIAO TSENG | 公開日期: | 2007 | 卷: | 37 | 期: | 11 | 起(迄)頁: | 870-877 | 來源出版物: | European Journal of Clinical Investigation | 摘要: | Background: Both type 2 diabetes mellitus (T2DM) and hypertension aggregate in families. It is a common thought that diabetic patients with parental diabetes and/or parental hypertension are more likely to develop hypertension. This study evaluated the separate and joint effects of parental hypertension and parental diabetes on the prevalence of hypertension in patients with T2DM. Materials and methods: A total of 89 956 patients from a national cohort were interviewed by telephone. Information about age, sex, onset age of diabetes, body height, body weight, systolic (SBP) and diastolic blood pressure (DBP), smoking, hypertension, and paternal and maternal history of diabetes and hypertension were obtained. Hypertension was defined in two ways: (1) a positive history; or (2) a positive history or a reported SBP ? 140 mmHg and/or DBP ? 90 mmHg in patients without a hypertension history. Results: While analysed separately in logistic models, both parental diabetes and parental hypertension were positively associated with hypertension. However, when both were analysed together, only parental hypertension was positively associated with hypertension, with paternal and maternal hypertension exerting a similar effect of an approximately 2.5-fold higher risk. While considering the effect of parental hypertension, both paternal and maternal diabetes was significantly associated with a lower risk of hypertension with odds ratios of approximately 0.8. Parental hypertension was also significantly associated with increased SBP and DBP; and parental diabetes with lower values in multiple linear regression. Conclusions: Parental hypertension is strongly associated with hypertension. However, parental diabetes may be protective if the effect of parental hypertension is considered. ? 2007 The Author. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-35649001533&doi=10.1111%2fj.1365-2362.2007.01875.x&partnerID=40&md5=7bd86da7dd0f2717723844606a5547d0 https://scholars.lib.ntu.edu.tw/handle/123456789/496176 |
ISSN: | 0014-2972 | DOI: | 10.1111/j.1365-2362.2007.01875.x | SDG/關鍵字: | adult; age distribution; article; body height; body mass; body weight; controlled study; diastolic blood pressure; disease association; disease duration; family history; female; health survey; human; hypertension; insulin dependent diabetes mellitus; interview; major clinical study; male; multiple linear regression analysis; non insulin dependent diabetes mellitus; onset age; priority journal; sex ratio; statistical significance; systolic blood pressure; Taiwan; Age of Onset; Aged; Blood Pressure; Body Weights and Measures; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Family Health; Female; Genetic Predisposition to Disease; Humans; Hypertension; Male; Middle Aged; Odds Ratio; Reproducibility of Results; Risk Factors; Smoking; Taiwan |
顯示於: | 醫學系 |
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