https://scholars.lib.ntu.edu.tw/handle/123456789/496184
標題: | Arsenic methylation capability and hypertension risk in subjects living in arseniasis-hyperendemic areas in southwestern Taiwan | 作者: | Huang Y.-K. CHIN-HSIAO TSENG Huang Y.-L. Yang M.-H. Chen C.-J. Hsueh Y.-M. |
公開日期: | 2007 | 卷: | 218 | 期: | 2 | 起(迄)頁: | 135-142 | 來源出版物: | Toxicology and Applied Pharmacology | 摘要: | Background: Cumulative arsenic exposure (CAE) from drinking water has been shown to be associated with hypertension in a dose-response pattern. This study further explored the association between arsenic methylation capability and hypertension risk among residents of arseniasis-hyperendemic areas in Taiwan considering the effect of CAE and other potential confounders. Method: There were 871 subjects (488 women and 383 men) and among them 372 were diagnosed as having hypertension based on a positive history or measured systolic blood pressure ? 140?mm?Hg and/or diastolic blood pressure ? 90?mm?Hg. Urinary arsenic species were determined by high-performance liquid chromatography-hydride generator and atomic absorption spectrometry. Primary arsenic methylation index [PMI, defined as monomethylarsonic acid (MMAV) divided by (AsIII + AsV)] and secondary arsenic methylation index (SMI, defined as dimethylarsinic acid divided by MMAV) were used as indicators for arsenic methylation capability. Results: The level of urinary arsenic was still significantly correlated with cumulative arsenic exposure (CAE) calculated from a questionnaire interview (p = 0.02) even after the residents stopped drinking the artesian well water for 2-3 decades. Hypertensive subjects had higher percentages of MMAV and lower SMI than subjects without hypertension. However, subjects having CAE > 0?mg/L-year had higher hypertension risk than those who had CAE = 0?mg/L-year disregard a high or low methylation index. Conclusion: Inefficient arsenic methylation ability may be related with hypertension risk. ? 2006 Elsevier Inc. All rights reserved. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-33846620625&doi=10.1016%2fj.taap.2006.10.022&partnerID=40&md5=e37aaab0b65cf28dbe44dd0b9ca4828e https://scholars.lib.ntu.edu.tw/handle/123456789/496184 |
ISSN: | 0041-008X | DOI: | 10.1016/j.taap.2006.10.022 | SDG/關鍵字: | arsenic; cacodylic acid; drinking water; methanearsonic acid; well water; adult; anamnesis; arsenic poisoning; article; atomic absorption spectrometry; calculation; correlation analysis; diastolic blood pressure; dose response; endemic disease; female; fluid intake; high performance liquid chromatography; human; hypertension; major clinical study; male; measurement; methylation; primary methylation index; questionnaire; risk assessment; risk factor; secondary methylation index; systolic blood pressure; Taiwan; water contamination; water pollutant; water supply; Adult; Age Factors; Aged; Alcohol Drinking; Arsenic; Arsenic Poisoning; Arsenicals; Blood Pressure; Cholesterol; Endemic Diseases; Female; Humans; Hypertension; Lipids; Male; Methylation; Middle Aged; Questionnaires; Risk Factors; Sex Factors; Smoking; Spectrophotometry, Atomic; Taiwan; Triglycerides |
顯示於: | 醫學系 |
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