https://scholars.lib.ntu.edu.tw/handle/123456789/496207
標題: | Independent association of uric acid levels with peripheral arterial disease in Taiwanese patients with Type 2 diabetes | 作者: | CHIN-HSIAO TSENG | 公開日期: | 2004 | 卷: | 21 | 期: | 7 | 起(迄)頁: | 724-729 | 來源出版物: | Diabetic Medicine | 摘要: | Aims: Hyperuricaemia may be a risk factor for atherosclerotic disease. Its association with peripheral arterial disease (PAD) has not been studied in Taiwanese patients with Type 2 diabetes. Methods: Uric acid (UA) levels and PAD were evaluated in 508 Taiwanese outpatients with Type 2 diabetes (210 men, 298 women; mean age ± SD, 63.8 ± 10.6 years). PAD was diagnosed when the ankle-brachial index was < 0.9. Patients with an ankle-brachial index of ? 1.3 were excluded because of possible medial arterial calcification. Potential confounding variables with P < 0.10 were adjusted for in multivariate analyses. Results: In univariate analyses, UA levels were higher in patients with PAD than in those without PAD (345.0 ± 95.2 vs. 309.3 ± 89.2 μmol/l; P < 0.0005). Prevalences of PAD for quintiles of UA levels were 6.8, 8.9, 10.2, 13.1 and 16.5%, respectively (P-trend < 0.05). With UA level as a continuous variable, the multivariate-adjusted odds ratio (95% confidence interval) for PAD was 1.005 (1.001-1.008) (P < 0.01). The optimal cut-off point for UA as determined by the receiver operating characteristic curve was 264.7 μmol/l. The sensitivity and specificity at this cut-off point was 82.6 and 33.3%, respectively. The area under curve was 0.60 (95% confidence interval: 0.53-0.68). The multivariate-adjusted odds ratio for PAD for UA above this level was 2.736 (1.239-6.043) (P < 0.05). The results after excluding 56 cases using diuretics were similar. Conclusions: Elevated uric acid level is a significant and independent risk factor for PAD in Taiwanese patients with Type 2 diabetes. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-3142775810&doi=10.1111%2fj.1464-5491.2004.01239.x&partnerID=40&md5=9a85f67a0ccdfef7dcc04928b2ae96d5 https://scholars.lib.ntu.edu.tw/handle/123456789/496207 |
ISSN: | 0742-3071 | DOI: | 10.1111/j.1464-5491.2004.01239.x | SDG/關鍵字: | diuretic agent; uric acid; adult; aged; area under the curve; artery disease; article; atherosclerosis; confidence interval; controlled study; female; human; hyperuricemia; major clinical study; male; medical assessment; multivariate analysis; non insulin dependent diabetes mellitus; outpatient; risk factor; uric acid blood level; Aged; Arterial Occlusive Diseases; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Female; Humans; Hyperuricemia; Male; Middle Aged; Peripheral Vascular Diseases; Risk Factors; Taiwan; Uric Acid |
顯示於: | 醫學系 |
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