Lipoprotein(a) Is an Independent Risk Factor for Peripheral Arterial Disease in Chinese Type 2 Diabetic Patients in Taiwan
Journal
Diabetes Care
Journal Volume
27
Journal Issue
2
Pages
517-521
Date Issued
2004
Author(s)
Abstract
OBJECTIVE - To examine the association between lipoprotein(a) [Lp(a)] and peripheral arterial disease (PAD) and determine the optimal cutoff in Chinese type 2 diabetic patients in Taiwan. RESEARCH DESIGN AND METHODS - Serum Lp(a) was determined in 557 type 2 diabetic patients (243 men and 314 women) recruited consecutively from a diabetes clinic at the National Taiwan University Hospital. Ankle-brachial index (ABI) <0.9 was diagnosed as PAD (n = 45) and <0.8 as severe PAD (n = 20). Potential confounders included age, sex, BMI, waist-to-hip ratio (WHR), diabetes duration, insulin usage, smoking, hypertension, systolic and diastolic blood pressure, fasting plasma glucose (FPG), total cholesterol, triglycerides, and HDL and LDL cholesterol. RESULTS - The distribution of Lp(a) was right skewed and no significant differences for sex, WHR, insulin usage, smoking, hypertension, and systolic and diastolic blood pressure were observed. In men, log[Lp(a)] was correlated positively with age, duration, and total and LDL cholesterol (borderline significant, P < 0.1) and negatively with BMI, triglycerides, and FPG (P < 0.1). In women, log[Lp(a)] was correlated positively with total and LDL cholesterol and negatively with triglycerides and BMI (P < 0.1). ABI was significantly correlated with log [Lp(a)], especially in men or in patients with PAD. The optimal cutoff determined by discriminant analysis was 13.3 mg/dl. Patients with Lp(a) above this value had a 2.7-fold higher risk of PAD after multivariate adjustment. Lp(a) also significantly increased from no PAD to mild and severe PAD (17.1 ± 14.4, 23.7 ± 20.3, and 36.9 ± 22.8 mg/dl, respectively, P < 0.001). CONCLUSIONS - Lp(a) is an independent risk factor for PAD in type 2 diabetic patients in Taiwan. The optimal cutoff is 13. 3 mg/dl.
SDGs
Other Subjects
cholesterol; high density lipoprotein cholesterol; lipoprotein A; low density lipoprotein cholesterol; triacylglycerol; adult; age; aged; ankle; anthropometric parameters; artery disease; article; body mass; cholesterol blood level; correlation analysis; disease association; disease severity; female; gender; human; insulin treatment; lipoprotein blood level; major clinical study; male; non insulin dependent diabetes mellitus; risk factor; sex difference; smoking; Taiwan; triacylglycerol blood level; university hospital; Asian Continental Ancestry Group; Blood Glucose; Blood Pressure; Cholesterol; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Female; Humans; Lipids; Lipoprotein(a); Male; Middle Aged; Multivariate Analysis; Peripheral Vascular Diseases; Risk Factors; Sex Characteristics; Taiwan
Type
journal article