https://scholars.lib.ntu.edu.tw/handle/123456789/496210
標題: | Lipoprotein(a) Is an Independent Risk Factor for Peripheral Arterial Disease in Chinese Type 2 Diabetic Patients in Taiwan | 作者: | CHIN-HSIAO TSENG | 公開日期: | 2004 | 卷: | 27 | 期: | 2 | 起(迄)頁: | 517-521 | 來源出版物: | Diabetes Care | 摘要: | OBJECTIVE - To examine the association between lipoprotein(a) [Lp(a)] and peripheral arterial disease (PAD) and determine the optimal cutoff in Chinese type 2 diabetic patients in Taiwan. RESEARCH DESIGN AND METHODS - Serum Lp(a) was determined in 557 type 2 diabetic patients (243 men and 314 women) recruited consecutively from a diabetes clinic at the National Taiwan University Hospital. Ankle-brachial index (ABI) <0.9 was diagnosed as PAD (n = 45) and <0.8 as severe PAD (n = 20). Potential confounders included age, sex, BMI, waist-to-hip ratio (WHR), diabetes duration, insulin usage, smoking, hypertension, systolic and diastolic blood pressure, fasting plasma glucose (FPG), total cholesterol, triglycerides, and HDL and LDL cholesterol. RESULTS - The distribution of Lp(a) was right skewed and no significant differences for sex, WHR, insulin usage, smoking, hypertension, and systolic and diastolic blood pressure were observed. In men, log[Lp(a)] was correlated positively with age, duration, and total and LDL cholesterol (borderline significant, P < 0.1) and negatively with BMI, triglycerides, and FPG (P < 0.1). In women, log[Lp(a)] was correlated positively with total and LDL cholesterol and negatively with triglycerides and BMI (P < 0.1). ABI was significantly correlated with log [Lp(a)], especially in men or in patients with PAD. The optimal cutoff determined by discriminant analysis was 13.3 mg/dl. Patients with Lp(a) above this value had a 2.7-fold higher risk of PAD after multivariate adjustment. Lp(a) also significantly increased from no PAD to mild and severe PAD (17.1 ± 14.4, 23.7 ± 20.3, and 36.9 ± 22.8 mg/dl, respectively, P < 0.001). CONCLUSIONS - Lp(a) is an independent risk factor for PAD in type 2 diabetic patients in Taiwan. The optimal cutoff is 13. 3 mg/dl. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0842311550&doi=10.2337%2fdiacare.27.2.517&partnerID=40&md5=d6cc82a03e5a246ed523c1925930bfe5 https://scholars.lib.ntu.edu.tw/handle/123456789/496210 |
ISSN: | 0149-5992 | DOI: | 10.2337/diacare.27.2.517 | SDG/關鍵字: | cholesterol; high density lipoprotein cholesterol; lipoprotein A; low density lipoprotein cholesterol; triacylglycerol; adult; age; aged; ankle; anthropometric parameters; artery disease; article; body mass; cholesterol blood level; correlation analysis; disease association; disease severity; female; gender; human; insulin treatment; lipoprotein blood level; major clinical study; male; non insulin dependent diabetes mellitus; risk factor; sex difference; smoking; Taiwan; triacylglycerol blood level; university hospital; Asian Continental Ancestry Group; Blood Glucose; Blood Pressure; Cholesterol; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Female; Humans; Lipids; Lipoprotein(a); Male; Middle Aged; Multivariate Analysis; Peripheral Vascular Diseases; Risk Factors; Sex Characteristics; Taiwan |
顯示於: | 醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。