https://scholars.lib.ntu.edu.tw/handle/123456789/496229
標題: | Long-term arsenic exporure and incidence of non-insulin-dependent diabetes mellitus: A cohort study in arseniasis-hyperendemic villages in Taiwan | 作者: | CHIN-HSIAO TSENG TONG-YUAN TAI Chong C.-K. Tseng C.-P. Lai M.-S. Lin B.J. Chiou H.-Y. Hsueh Y.-M. Hsu K.-H. Chen C.-J. |
關鍵字: | Diabetes mellitus; Incidence; Ingested arsenic; Oral glucose tolerance test; Water pollutant | 公開日期: | 2000 | 出版社: | Public Health Services, US Dept of Health and Human Services | 卷: | 108 | 期: | 9 | 起(迄)頁: | 847-851 | 來源出版物: | Environmental Health Perspectives | 摘要: | Diabetes prevalence in arseniasis-hyperendemic villages in Taiwan has been reported to be significantly higher than in the general population. The aim of this cohort study was to further evaluate the association between ingested inorganic arsenic and the incidence of non-insulin-dependent diabetes mellitus in these villages. A total of 446 nondiabetic residents in these villages were followed biannually by oral glucose tolerance test. Diabetes is defined as a fasting plasma glucose level ?7.8 mmol/L and/or a 2-hr post-load glucose level ? 11.1 mmol/L. During the follow-up period of 1499.5 person-years, 41 cases developed diabetes, showing an overall incidence of 27.4/1,000 person-years. The incidence of diabetes correlated with age, body mass index, and cumulative arsenic exposure. The multivariate-adjusted relative risks were 1.6, 2.3, and 2.1 for age ?55 versus < 55 years, a body mass index ? 25 versus < 25 kg/m2, and a cumulative arsenic exposure ? 17 versus < 17 mg/L-years, respectively. The incidence density ratios (95% confidence intervals) between the hyperendemic villages and the two nonendemic control townships were 3.6 (3.5-3.6), 2.3 (1.1-4.9), 4.3 (2.4-7.7), and 5.5 (2.2-13.5), respectively, for the age groups of 35-44, 45-54, 55-64, and 65-74 years. The findings are consistent with our previous cross-sectional observation that ingested inorganic arsenic is diabetogenic in human beings. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0033766418&doi=10.1289%2fehp.00108847&partnerID=40&md5=e422abe5bfc12c5aba8bf3d066046d4e https://scholars.lib.ntu.edu.tw/handle/123456789/496229 |
ISSN: | 0091-6765 | DOI: | 10.1289/ehp.00108847 | SDG/關鍵字: | arsenic; glucose; inorganic compound; adult; aged; article; cohort analysis; controlled study; diabetogenesis; dietary intake; disease predisposition; endemic disease; environmental exposure; female; follow up; food contamination; human; incidence; major clinical study; male; non insulin dependent diabetes mellitus; oral glucose tolerance test; population research; prevalence; priority journal; risk assessment; Taiwan |
顯示於: | 醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。