Assessment of glomerular filtration rate based on alterations of serum brain-derived neurotrophic factor in type 2 diabetic subjects treated with amlodipine/benazepril or valsartan/hydrochlorothiazide
Journal
Disease Markers
Journal Volume
2015
Pages
780743
Date Issued
2015
Author(s)
Abstract
Background. Brain-derived neurotrophic factor (BDNF) is associated with sympathetic activation. However, the effects of BDNF on diabetic nephropathy are unknown. The aim of this study was to assess the estimated glomerular filtration rates (eGFRs) and changes in serum BDNF levels in type 2 diabetic subjects treated with antihypertensive medications. Methods. In this randomized, double-blind clinical trial, type 2 diabetic subjects with hypertension were assigned to either the benazepril/amlodipine or valsartan/hydrochlorothiazide treatment groups for a 16-week period. The post hoc analyses were based on increased or decreased serum BDNF levels. Results. Of the 153 enrolled subjects, the changes in eGFR were significantly and inversely correlated with those in BDNF in the 76 subjects treated with valsartan/hydrochlorothiazide (r=-0.264, P=0.021) but not in the 77 subjects treated with benazepril/amlodipine (r=-0.025, P=0.862). The 45 subjects with increased BDNF following valsartan/hydrochlorothiazide treatment exhibited a significantly reduced eGFR (-8.8±14.9 mL/min/1.73 m2; P<0.001). Multivariate regression analysis revealed that increased serum BDNF represents an independent factor for reduced eGFR (95% confidence interval between -0.887 and -0.076, P=0.020). Conclusions. Increased serum BDNF is associated with reduced eGFR in type 2 diabetic subjects treated with valsartan/hydrochlorothiazide but not with amlodipine/benazepril. ? 2015 I-Te Lee et al.
SDGs
Other Subjects
amlodipine plus benazepril; brain derived neurotrophic factor; hydrochlorothiazide plus valsartan; amlodipine; antihypertensive agent; benazepril; benzazepine derivative; brain derived neurotrophic factor; hydrochlorothiazide; valsartan; adult; antihypertensive therapy; Article; controlled study; diabetic hypertension; double blind procedure; female; glomerulus filtration rate; human; major clinical study; male; middle aged; multicenter study; non insulin dependent diabetes mellitus; post hoc analysis; priority journal; protein blood level; randomized controlled trial; treatment outcome; aged; blood; chemically induced; Diabetes Mellitus, Type 2; diabetic nephropathy; Aged; Amlodipine; Antihypertensive Agents; Benzazepines; Brain-Derived Neurotrophic Factor; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Female; Glomerular Filtration Rate; Humans; Hydrochlorothiazide; Male; Middle Aged; Valsartan
Publisher
Hindawi Limited
Type
journal article