https://scholars.lib.ntu.edu.tw/handle/123456789/496305
標題: | Basal insulin therapy: Unmet medical needs in Asia and the new insulin glargine in diabetes treatment | 作者: | Tien K.-J. Hung Y.-J. Chen J.-F. Chen C.-C. CHIH-YUAN WANG Hwu C.-M. Huang Y.-Y. Hsiao P.-J. Tu S.-T. Wang C.-H. Sheu W.H.-H. |
關鍵字: | Asians; Diabetes; Insulin glargine | 公開日期: | 2019 | 出版社: | Blackwell Publishing | 卷: | 10 | 期: | 3 | 起(迄)頁: | 560-570 | 來源出版物: | Journal of Diabetes Investigation | 摘要: | Diabetes remains a global epidemic and a tremendous health challenge, especially in the Asian population. Dramatic increases in the prevalence of diabetes across different countries or areas in Asia have been reported in recent epidemiological studies. Although clinical guidelines have strengthened appropriate antihyperglycemic medications and lifestyle modifications for optimal diabetes management, inadequate glycemic control still occurs in many patients with an increased risk of developing microvascular and macrovascular complications. Insulin administration is the main therapy for diabetes in response to the inability to secrete insulin, and is recommended in current guidelines to treat patients with type?2 diabetes after failure of oral antidiabetic drugs. Clinical studies have shown that long-acting insulin analogs improve basal glycemic control with reduced risk of hypoglycemia. In the present review, we discuss previous challenges with basal insulin therapy in Asia, the pharmacological development of insulin analogs to overcome the unmet medical needs and recent clinical studies of the new ultra-long-acting insulin analog, insulin glargine U300. Furthermore, relevant findings of current real-world evidence are also included for the comparison of the efficacy and safety of different insulin formulations. Based on the accumulating evidence showing a low incidence of hypoglycemia and technical benefits of dose titration, treatment with glargine U300 can be a promising strategy for Asian diabetes patients to achieve glycemic targets with favorable safety. ? 2018 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85060252091&doi=10.1111%2fjdi.12984&partnerID=40&md5=4ce05d27778ad9df5ba35ad68f767cc2 https://scholars.lib.ntu.edu.tw/handle/123456789/496305 |
ISSN: | 2040-1116 | DOI: | 10.1111/jdi.12984 | SDG/關鍵字: | glucose; insulin degludec; insulin detemir; insulin glargine; metformin; antidiabetic agent; insulin glargine; Asia; clinical effectiveness; clinical practice; drug safety; drug tolerability; ethnic difference; evidence based medicine; glucose blood level; glycemic control; health care need; human; hypoglycemia; insulin treatment; lifestyle modification; non insulin dependent diabetes mellitus; pharmacodynamic parameters; pharmacokinetic parameters; practice guideline; priority journal; Review; treatment failure; Asia; diabetes mellitus; needs assessment; prognosis; Asia; Diabetes Mellitus; Humans; Hypoglycemic Agents; Insulin Glargine; Needs Assessment; Prognosis |
顯示於: | 醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。