https://scholars.lib.ntu.edu.tw/handle/123456789/496344
標題: | Serum levels of pepsinogen I in healthy volunteers and patients with gastric ulcers and gastric carcinoma in Taiwan. | 作者: | MING-SHIANG WU Lin J.T. JIN-TOWN WANG Huang S.C. CHIH-YUAN WANG Wang T.H. |
公開日期: | 1993 | 卷: | 92 | 期: | 8 | 起(迄)頁: | 711-716 | 來源出版物: | Journal of the Formosan Medical Association = Taiwan yi zhi | 摘要: | In order to investigate the clinical usefulness of human pepsinogen I (PGI) as a noninvasive diagnostic tool for gastric lesions, 92 healthy volunteers, 87 patients with a gastric ulcer and 94 patients with gastric carcinoma, verified by histologic examinations, were enrolled. The serum level of PGI in each patient was measured by radioimmunoassay. Mean serum PGI levels were 95.4 +/- 39.4 ng/mL in patients with gastric ulcers, 77.6 +/- 29.3 ng/mL in healthy volunteers, and 52.1 +/- 26.5 ng/mL in patients with gastric carcinoma. Statistically significant differences (p < 0.01) existed between the two groups. Various factors which affect serum PGI levels, including age, sex, smoking habit, blood type, and Helicobacter pylori (H. pylori) infection, were also analyzed in each group. The serum levels of PGI were not affected by gender or blood type in any of the three groups (p > 0.05). A negative correlation of serum PGI levels with age was observed in patients with carcinoma (r = -0.43, p < 0.01). Smokers in the gastric ulcer group had significantly higher levels of PGI than nonsmokers (106.2 +/- 35.9 ng/mL vs 83.2 +/- 32.3 ng/mL, p < 0.05). A significantly higher PGI concentration was found in both H. pylori infected asymptomatic volunteers and gastric carcinoma patients (82.9 +/- 29.8 ng/mL vs 67.6 +/- 26.0 ng/mL, and 56.5 +/- 26.7 ng/mL vs 43.6 +/- 24.3 ng/mL, p < 0.05).(ABSTRACT TRUNCATED AT 250 WORDS) |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0027640377&partnerID=40&md5=086695af2c320a0671f99f2d731636f4 https://scholars.lib.ntu.edu.tw/handle/123456789/496344 |
ISSN: | 0929-6646 | SDG/關鍵字: | pepsinogen; adult; aged; article; blood; differential diagnosis; enzyme assay; enzymology; female; human; male; middle aged; radioimmunoassay; reference value; stomach tumor; stomach ulcer; Taiwan; Adult; Aged; Diagnosis, Differential; Enzyme Tests; Female; Humans; Male; Middle Aged; Pepsinogens; Radioimmunoassay; Reference Values; Stomach Neoplasms; Stomach Ulcer; Taiwan |
顯示於: | 醫學系 |
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