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  1. NTU Scholars
  2. 醫學院
  3. 醫學系
Please use this identifier to cite or link to this item: https://scholars.lib.ntu.edu.tw/handle/123456789/496597
Title: The impact of locoregional recurrences and distant metastases on the survival of patients with papillary thyroid carcinoma
Authors: Su D.-H.
Chang S.-H.
TIEN-CHUN CHANG 
Issue Date: 2015
Publisher: Blackwell Publishing Ltd
Journal Volume: 82
Journal Issue: 2
Start page/Pages: 286-294
Source: Clinical Endocrinology
Abstract: 
Objective Some patients with papillary thyroid carcinoma (PTC) would suffer from locoregional recurrences or distant metastases. This study was aimed to elucidate the impacts of locoregional recurrences and distant metastases on these patients' survival. Design Retrospective hospital-based cohort study. Population Data were collected from 1636 subjects with PTC at National Taiwan University Hospital between 1985 and 2007. Measurements Overall and disease-specific survival curves were estimated by the Kaplan-Meier method. Time-independent and time-dependent prognostic factors were included simultaneously in multivariate analyses using Cox models. Results Overall survival (OS) rates at 10- and 20-years were 90% and 76%, respectively. The 10- and 20-year disease-specific survival (DSS) rates were 95% and 90%, respectively. Our multivariate analyses identified that older age, distant metastases (hazard ratio, HR: 6·69, 95% CI: 4·40-10·18), locoregional recurrences (HR: 1·88, 95% CI: 1·22-2·89), lymph node metastases, massive extrathyroid extension, male gender and larger tumour size (>4 cm) were significantly associated with poorer OS. Older age, distant metastases (HR: 15·03, 95% CI: 8·31-27·21), locoregional recurrences (HR: 3·63, 95% CI: 2·03-6·51), massive extrathyroid extension, male gender and larger tumour size (>4 cm) were independently related to worse DSS. The performance of high-dose 131I ablation had a protective effect on OS and DSS. Conclusion The locoregional recurrences had a moderately harmful impact on OS and DSS, but age and distant metastases were the major decisive factors for OS and DSS. High-dose 131I ablation had a protective role. However, lymph node dissection did not alter the prognosis whenever lymph node metastases only influenced OS. ? 2014 The Authors. Clinical Endocrinology published by John Wiley & Sons Ltd.
URI: https://www.scopus.com/inward/record.uri?eid=2-s2.0-84921598726&doi=10.1111%2fcen.12511&partnerID=40&md5=3e42789682348f975027b11a400468b5
https://scholars.lib.ntu.edu.tw/handle/123456789/496597
ISSN: 0300-0664
DOI: 10.1111/cen.12511
metadata.dc.subject.other: iodine 131; radioactive iodine; adult; aging; Article; cancer prognosis; cancer recurrence; cancer survival; cohort analysis; correlation analysis; disease specific survival; distant metastasis; female; human; locoregional recurrence; long term survival; lymph node metastasis; major clinical study; male; overall survival; priority journal; retrospective study; risk factor; sex difference; thyroid carcinoma; thyroidectomy; tumor ablation; tumor invasion; tumor volume; carcinoma; epidemiology; lymph node dissection; metastasis; middle aged; mortality; pathology; statistics and numerical data; survival; Taiwan; Thyroid Neoplasms; tumor recurrence; Adult; Carcinoma; Female; Humans; Iodine Radioisotopes; Lymph Node Excision; Male; Middle Aged; Neoplasm Metastasis; Neoplasm Recurrence, Local; Retrospective Studies; Survival Analysis; Taiwan; Thyroid Neoplasms; Thyroidectomy
[SDGs]SDG3
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臺大位居世界頂尖大學之列,為永久珍藏及向國際展現本校豐碩的研究成果及學術能量,圖書館整合機構典藏(NTUR)與學術庫(AH)不同功能平台,成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。

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總館學科館員 (Main Library)
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開放取用是從使用者角度提升資訊取用性的社會運動,應用在學術研究上是透過將研究著作公開供使用者自由取閱,以促進學術傳播及因應期刊訂購費用逐年攀升。同時可加速研究發展、提升研究影響力,NTU Scholars即為本校的開放取用典藏(OA Archive)平台。(點選深入了解OA)

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