https://scholars.lib.ntu.edu.tw/handle/123456789/496603
標題: | Graves' ophthalmopathy: From pathogenesis to management | 作者: | TIEN-CHUN CHANG | 關鍵字: | Computed tomography; Glycosaminoglycan; Graves' disease; Graves' ophthalmopathy | 公開日期: | 2013 | 卷: | 24 | 期: | 4 | 起(迄)頁: | 258-264 | 來源出版物: | Journal of Internal Medicine of Taiwan | 摘要: | Hyperthyroidism, Graves' ophthalmopathy and pretibial myxedema are three major manifestations of Graves' disease. TSH receptor antibody stimulates TSH receptors on the follicular cells of the thyroid to over produce thyroid hormones, resulting hyperthyroidism. However, the etiology of Graves' ophthalmopathy and pretibial myxedema is not so clear. It is quite clear that Graves' ophthalmopathy is an autoimmune disease. It may be related to the action of T cells with TSH receptors on retrobulbar fibroblasts and adipocytes, and T cells produce cytokines to stimulate fibroblasts to secrete glycosaminoglycans which absorb water to make swelling of extraocular muscles and retrobulbar tissues. Orbital computed tomography is an important method to examine Graves' ophthalmopathy. In addition, the activity of Graves' ophthalmopathy should be evaluated. If it is in active stage, high dose of corticosteroid could be used. If it is inactive, but still symptomatic, surgery may be necessary. The patient should be kept in euthyroid state at any stage. In conclusion, the management of Graves' ophthalmopathy should be managed by team work to get the best result. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84887110105&partnerID=40&md5=4509dfd7f008608d4a4e5c960cc7db7f https://scholars.lib.ntu.edu.tw/handle/123456789/496603 |
ISSN: | 1016-7390 | SDG/關鍵字: | corticosteroid; glycosaminoglycan; thyrotropin receptor; adipocyte; article; computer assisted tomography; corticosteroid therapy; cytokine production; drug megadose; endocrine ophthalmopathy; euthyroidism; extraocular muscle; fibroblast; human; pathogenesis; swelling; T lymphocyte; water absorption |
顯示於: | 醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。