https://scholars.lib.ntu.edu.tw/handle/123456789/496701
標題: | Three-dimensional cytomorphology and its relationship with clinical stage in fine needle aspiration biopsy of papillary thyroid carcinoma | 作者: | TIEN-CHUN CHANG Lai S.-M. Wen C.-Y. Hsiao Y.-L. Huang S.-H. |
公開日期: | 2000 | 出版社: | S. Karger AG | 卷: | 44 | 期: | 4 | 起(迄)頁: | 633-639 | 來源出版物: | Acta Cytologica | 摘要: | Objective: To elucidate three-dimensional (3-D) cytomorphology and its relationship with clinical stage in fine needle aspiration biopsy (FNAB) of papillary thyroid carcinoma (PTC). Study Design: FNAB was performed in tumors from 34 patients with PTC. The aspirate was stained and observed under a light microscope (LM). The aspirate was also fixed, dehydrated, critical point dried, spattered with gold ions and observed with a scanning electron microscope (SEM). Findings under SEM were correlated with the presentation under LM and also with clinical stage. As a control, FNAB was also performed on a normal part of the thyroid in six patients. Results: Under SEM, normal thyroid cells appeared as round, scattered cells or sheets with a uniform honeycomb cellular arrangement. In PTC, cell sheets with uniform nuclear morphology under LM usually showed a uniform cell arrangement and with distinct cell borders under SEM. Cell sheets with nuclear pleomorphism under LM usually showed a more-disorganized arrangement and with indistinct cell borders under SEM. PTC at advanced clinical stages usually presented with a disorganized cell arrangement, indistinct cell borders and loss of microvilli. Conclusion: 3-D cytomorphology in FNAB of PTC was related to clinical stage and might be a prognostic factor for PTC. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0033898921&doi=10.1159%2f000328539&partnerID=40&md5=cc04d8eed56978777f319117f4d24788 https://scholars.lib.ntu.edu.tw/handle/123456789/496701 |
ISSN: | 0001-5547 | DOI: | 10.1159/000328539 | SDG/關鍵字: | adult; aged; article; aspiration biopsy; aspiration cytology; cancer cytodiagnosis; cancer staging; carcinoma cell; cell structure; controlled study; diagnostic procedure; female; human; human cell; male; priority journal; prognosis; thyroid cell; thyroid papillary carcinoma |
顯示於: | 醫學系 |
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