https://scholars.lib.ntu.edu.tw/handle/123456789/496809
標題: | Low dose HIV-1 Tat improves the defective nuclear factor (NF)-κB activity of dendritic cells from persons with spinal cord injury | 作者: | SZU-MIN HSIEH Wang Y.-H. SHAN-CHWEN CHANG TIEN-SHANG HUANG |
公開日期: | 2009 | 卷: | 257 | 期: | 43832 | 起(迄)頁: | 105-110 | 來源出版物: | Cellular Immunology | 摘要: | Deficits of immune function may be involved in the infections associated with spinal cord injury (SCI). Previous report showed that the impaired maturation potential of dendritic cells (DCs) contributes to immune defect in persons with SCI, especially in those with tetraplegia. To evaluate the roles of cell signaling in the impaired maturation potential of DCs, we assessed the phenotypic and functional maturation potential of DCs in 20 subjects with trauma-induced stable SCI and their neurologically intact healthy control in the presence of DC stimulators, including HIV-1 Tat protein (Tat). Our results showed the tetraplegic subjects had an impaired maturation potential of DCs. The impairment could be attributed to insufficient nuclear factor (NF)-κB activity. The maturation potentials and NF-κB activity of DCs in response to stimulators could be improved by pretreatment with Tat, although Tat did not increase DC maturation. The improvement by Tat pretreatment was inhibited by a specific NF-κB blocker. We concluded that HIV-1 Tat could improve the maturation potentials of DCs from tetraplegic subjects, through Tat-induced enhancement of NF-κB activity. These data suggest a potential therapeutic role of HIV-1 Tat in improving immune function in tetraplegic persons. ? 2009 Elsevier Inc. All rights reserved. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-65049083417&doi=10.1016%2fj.cellimm.2009.03.005&partnerID=40&md5=65d395ca496291c3cbab260cb6d269b1 https://scholars.lib.ntu.edu.tw/handle/123456789/496809 |
ISSN: | 0008-8749 | DOI: | 10.1016/j.cellimm.2009.03.005 | SDG/關鍵字: | CD83 antigen; immunoglobulin enhancer binding protein; mitogen activated protein kinase 1; mitogen activated protein kinase 3; mitogen activated protein kinase p38; phospholipase C gamma; recombinant human immunodeficiency virus 1 transactivator protein; recombinant protein; transactivator protein; unclassified drug; adult; aged; antigen expression; article; cell maturation; cell stimulation; clinical article; controlled study; dendritic cell; drug mechanism; enzyme activity; human; human cell; priority journal; quadriplegia; signal transduction; spinal cord injury; Adult; Aged; Cell Proliferation; Dendritic Cells; Humans; Lipopolysaccharides; Middle Aged; NF-kappa B; Quadriplegia; Recombinant Proteins; Signal Transduction; Spinal Cord Injuries; T-Lymphocytes, Cytotoxic; tat Gene Products, Human Immunodeficiency Virus; Human immunodeficiency virus 1 |
顯示於: | 醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。