https://scholars.lib.ntu.edu.tw/handle/123456789/496812
標題: | Physical Distress, Emotional Status, and Quality of Life in Patients With Nasopharyngeal Cancer Complicated by Post-Radiotherapy Endocrinopathy | 作者: | Lue B.-H. TIEN-SHANG HUANG Chen H.-J. |
公開日期: | 2008 | 卷: | 70 | 期: | 1 | 起(迄)頁: | 28-34 | 來源出版物: | International Journal of Radiation Oncology Biology Physics | 摘要: | Purpose: To explore factors affecting quality of life (QOL) among patients with nasopharyngeal cancer (NPC) complicated by post-radiotherapy endocrinopathy. Methods and Materials: This cross-sectional study was conducted in a tertiary medical center and involved a total of 43 post-radiotherapy, recurrence-free NPC patients with endocrinopathy. They performed self-assessment of their emotional status using the Beck Anxiety Inventory and Beck Depression Inventory-II, and their QoL with the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30) questionnaire and the H&N35 cancer module. Results: Emotional and cognitive functioning of EORTC QLQ-C30 were the most affected. Fatigue, insomnia, and pain were the main concerns. Of the patients, 22 (51.2%) had anxiety and 19 (44.2%) had depression. Both depression and anxiety were negatively correlated with functional scales and global QoL but positively correlated with symptom scales. Multiple linear regression analysis revealed that physical distress symptoms of QLQ-C30 and physical functioning were the significant predictors of global QoL. Emotional and social functioning could predict depression, whereas emotional and physical functioning were significant predictors of anxiety. Conclusions: NPC patients with post-radiotherapy endocrinopathy exhibit impaired cognitive function and negative emotions. Symptoms of physical distress play an important role in QoL perception. Measurement of EORTC QLQ-C30 can be a useful instrument for the early detection of patients' impaired cognitive function and psychological morbidity. The high psychological distress related to the endocrine disturbances or the impact of NPC itself needs further study. ? 2008 Elsevier Inc. All rights reserved. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-37049000597&doi=10.1016%2fj.ijrobp.2007.06.053&partnerID=40&md5=a820591aef372b4a8edadd1ca0c1aa77 https://scholars.lib.ntu.edu.tw/handle/123456789/496812 |
ISSN: | 0360-3016 | DOI: | 10.1016/j.ijrobp.2007.06.053 | SDG/關鍵字: | Biological organs; Oncology; Patient monitoring; Radiotherapy; Endocrinopathy; Nasopharyngeal cancer; Psychological distress; Quality of life; Symptom distress; Tumors; adult; aged; article; Beck Anxiety Inventory; Beck Depression Inventory; cancer radiotherapy; clinical article; cognition; distress syndrome; emotion; endocrine disease; fatigue; female; human; insomnia; male; nasopharynx cancer; pain; priority journal; quality of life; questionnaire; radiation injury; self evaluation; social interaction; symptom; Adrenal Insufficiency; Adult; Aged; Anxiety; Cross-Sectional Studies; Depression; Endocrine System Diseases; Female; Growth Hormone; Humans; Hyperprolactinemia; Hypogonadism; Hypothyroidism; Male; Middle Aged; Nasopharyngeal Neoplasms; Pain; Psychiatric Status Rating Scales; Quality of Life; Regression Analysis; Sickness Impact Profile; Sleep Initiation and Maintenance Disorders |
顯示於: | 醫學系 |
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