https://scholars.lib.ntu.edu.tw/handle/123456789/496820
標題: | Hypopituitarism: A sequela of severe hypoxic encephalopathy | 作者: | Su D.-H. Liao K.-M. Chen H.-W. TIEN-SHANG HUANG |
公開日期: | 2006 | 出版社: | Scientific Communications International Ltd | 卷: | 105 | 期: | 7 | 起(迄)頁: | 536-541 | 來源出版物: | Journal of the Formosan Medical Association | 摘要: | Background/Purpose: Central diabetes insipidus (DI) is an established phenomenon after hypoxic encephalopathy or brain death, but hypopituitarism is seldom described. This study investigated the characteristics of 11 patients with DI and hypopituitarism which developed after severe hypoxic encephalopathy. Methods: The medical records of patients with DI and hypopituitarism after severe hypoxic encephalopathy from 1997 to 2002 were retrospectively reviewed. Eleven patients with DI and hypopituitarism after severe hypoxic episodes were included. Demographic data, primary diagnosis, the time of onset of DI, the time of diagnosis of hypopituitarism, the presence of symptoms of hypopituitarism, and outcome of these patients were analyzed. Results: Eleven patients comprising nine females and two males aged 47.4 ± 19.3 years (range, 24-74 years) were included. The mean interval from the precipitating event to the onset of DI was 60 ± 46 hours (range, 11-131 hours). The mean interval from the precipitating event to the diagnosis of hypopituitarism was 423 ± 182 hours (range, 132-672 hours). The average duration of hospitalization was 63 ± 35 days (range, 9-113 days). The overall mortality rate during hospitalization was 45%. Four patients died of sepsis and one died of heart failure due to acute myocardial infarction. Conclusion: The development of DI after severe hypoxic encephalopathy is a sign of severe brain damage. It usually ensues immediately or days after loss of brain stem reflexes. Hypopituitarism developed several weeks later than DI in these patients. Recognition and treatment of these deficiencies may prevent organ dysfunction. ? 2006 Elsevier & Formosan Medical Association. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-33746961272&doi=10.1016%2fS0929-6646%2809%2960147-9&partnerID=40&md5=556302d4d0b4f17b9813619b8a8aecac https://scholars.lib.ntu.edu.tw/handle/123456789/496820 |
ISSN: | 0929-6646 | DOI: | 10.1016/S0929-6646(09)60147-9 | SDG/關鍵字: | adrenalin; dopamine; inotropic agent; noradrenalin; acute heart infarction; adult; aged; article; brain hypoxia; brain stem; clinical article; clinical feature; demography; diabetes insipidus; disease severity; female; heart failure; hospitalization; human; hypopituitarism; male; medical record; medical record review; mortality; retrospective study; sepsis; sympathetic reflex; treatment outcome |
顯示於: | 醫學系 |
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