Methimazole-induced pulmonary hemorrhage associated with antimyeloperoxidase-antineutrophil cytoplasmic antibody: A case report
Journal
Journal of the Formosan Medical Association
Journal Volume
100
Journal Issue
11
Pages
772-775
Date Issued
2001
Author(s)
Abstract
Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis has been recently recognized in Graves' disease patients treated with antithyroid drugs. We describe the case of an 18-year-old girl who developed antimyeloperoxidase ANCA (MPO-ANCA)-positive vasculitis manifesting as a skin lesion and hemoptysis with hypoxic respiratory failure after taking methimazole. An open lung biopsy was consistent with acute capillaritis. Both skin and sural nerve biopsy showed lymphocytic vasculitis. Administration of steroid and plasmapheresis produced a good clinical response.
SDGs
Other Subjects
antithyroid agent; autoantibody; myeloperoxidase antibody; neutrophil cytoplasmic antibody; phenylthiourea; propranolol; steroid; thiamazole; unclassified drug; adult; article; case report; controlled study; disease association; female; Graves disease; hemoptysis; human; human tissue; hypoxia; lung biopsy; lung capillary; lung hemorrhage; plasmapheresis; respiratory failure; skin biopsy; skin disease; sural nerve; treatment outcome; vasculitis; Adolescent; Antibodies, Antineutrophil Cytoplasmic; Antithyroid Agents; Autoantibodies; Female; Hemorrhage; Humans; Lung Diseases; Methimazole; Peroxidase; Skin Diseases, Vascular; Vasculitis
Type
journal article