https://scholars.lib.ntu.edu.tw/handle/123456789/498839
標題: | A Portable Micro Gas Chromatography System for Lung Cancer Associated Volatile Organic Compound Detection. | 作者: | Tzeng, Te-Hsuen Kuo, Chun-Yen Wang, San-Yuan Huang, Po-Kai Huang, Yen-Ming Hsieh, Wei-Che Huang, Yu-Jie Kuo, Po-Hung Yu, Shih-An Lee, Si-Chen Tseng, Yufeng Jane Tian, Wei-Cheng SHEY-SHI LU YUFENG JANE TSENG WEI-CHENG TIAN SI-CHEN LEE |
公開日期: | 2016 | 卷: | 51 | 期: | 1 | 起(迄)頁: | 259-272 | 來源出版物: | J. Solid-State Circuits | 摘要: | With the help of micro-electromechanical systems (MEMS) and complementary metal-oxide-semiconductor (CMOS) technology, a portable micro gas chromatography (μGC) system for lung cancer associated volatile organic compounds (VOCs) detection is realized for the first time. The system is composed of an MEMS preconcentrator, an MEMS separation column, and a CMOS system-on-chip (SoC). The preconcentrator provides a concentration ratio of 2170. The separation column can separate more than seven types of lung cancer associated VOCs. The SoC is fabricated by a TSMC 0.35 μm 2P4M process including the CMOS VOCs detector, sensor calibration circuit, low-noise chopper instrumentation amplifier (IA), 10 bit analog to digital converter, and the microcontrol unit (MCU). Experimental results show that the system is able to detect seven types of lung cancer associated VOCs (acetone, 2-butanone, benzene, heptane, toluene, m-xylene, 1,3,5-trimethylbenzene). The concentration linearity is R2 = 0.985 and the detection sensitivity is up to 15 ppb with 1,3,5-trimethylbenzene. ? 2015 IEEE. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/498839 | DOI: | 10.1109/JSSC.2015.2489839 | SDG/關鍵字: | Acetone; Amplifiers (electronic); Analog to digital conversion; Application specific integrated circuits; Biological organs; Choppers (circuits); Chromatography; Diseases; MEMS; Metals; Microprocessor chips; MOS devices; Organic compounds; Programmable logic controllers; Separation; System-on-chip; Volatile organic compounds; 1 ,3 ,5-Trimethylbenzene; Analog to digital converters; Complementary metal-oxide-semiconductor technologies; Concentration ratio; Detection sensitivity; Instrumentation amplifier; Micro electromechanical system (MEMS); Micro-gas chromatography; Gas chromatography |
顯示於: | 電機工程學系 |
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