https://scholars.lib.ntu.edu.tw/handle/123456789/502654
標題: | Overexpression of SOX4 correlates with poor prognosis of acute myeloid leukemia and is leukemogenic in zebrafish | 作者: | Lu J.-W. Hsieh M.-S. HSIN-AN HOU Chen, Chien-Yuan HWEI-FANG TIEN LIANG-IN LIN |
公開日期: | 2017 | 卷: | 7 | 期: | 8 | 起(迄)頁: | e593 | 來源出版物: | Blood Cancer Journal | 摘要: | The SOX4 transcription factor is a key regulator of embryonic development, cell-fate decision, cellular differentiation and oncogenesis. Abnormal expression of SOX4 is related to malignant tumor transformation and cancer metastasis. However, no reports are available regarding the clinical significance of SOX4 in acute myeloid leukemia (AML) and the role of SOX4 in leukemogenesis. In the current study, we found that AML patients with low bone marrow (BM) SOX4 expression had higher remission rates and longer overall survival than those with high SOX4 expression, regardless of age, white blood cell count at diagnosis, karyotype profile and NPM1/FLT3-ITD status. To elucidate the role of SOX4 in leukemogenesis, we generated a transgenic zebrafish model that overexpressed human SOX4 in the myeloid lineage Tg(spi1-SOX4-EGFP). These transgenic zebrafish showed, at 5 months of age, increased myelopoiesis with dedifferentiation in kidney marrow. At 9 months of age, their kidney structure was significantly effaced and distorted by increased infiltration of myeloid progenitor cells. These results suggest that SOX4 is not only an independent prognostic factor of AML, but also an important molecular factor in leukemogenesis. ? 2017 The Author(s). |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/502654 | ISSN: | 2044-5385 | DOI: | 10.1038/bcj.2017.74 | SDG/關鍵字: | CD135 antigen; messenger RNA; nucleophosmin; transcription factor Sox4; transcription factor Sox; tumor protein; zebrafish protein; acute myeloid leukemia; adult; animal experiment; animal model; animal tissue; Article; bone marrow cell; cancer patient; cancer prognosis; cell dedifferentiation; cell infiltration; controlled study; de novo acute myeloid leukemia; disease free survival; embryo; follow up; human; immunocytochemistry; in situ hybridization; induction chemotherapy; karyotype; karyotyping; kidney structure; leukemogenesis; leukocyte count; major clinical study; microscopy; myeloid progenitor cell; myelopoiesis; nonhuman; overall survival; patient; polymerase chain reaction; protein expression; quantitative analysis; remission; reverse transcription polymerase chain reaction; tissue section; zebra fish; acute myeloid leukemia; animal; biosynthesis; gene expression regulation; genetics; metabolism; myelopoiesis; pathology; transgenic animal; Animals; Animals, Genetically Modified; Gene Expression Regulation, Neoplastic; Leukemia, Myeloid, Acute; Myelopoiesis; Neoplasm Proteins; SOXC Transcription Factors; Zebrafish; Zebrafish Proteins |
顯示於: | 醫學檢驗暨生物技術學系 |
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