JMJD2B as a potential diagnostic immunohistochemical marker for hepatocellular carcinoma: A tissue microarray-based study
Journal
Acta Histochemica
Journal Volume
117
Journal Issue
1
Pages
14-19
Date Issued
2015
Author(s)
Abstract
The purpose of this study was to examine JMJD2B expression in human hepatocellular carcinoma (HCC) and elucidate relationships between various expression patterns and clinicopathological parameters of HCC patients. Immunohistochemical techniques were performed to detect JMJD2B expression in a tissue microarray from patients with breast, cerebrum, colon, esophagus, kidney, liver, lung, prostate, stomach, and uterus cancers. We performed immunohistochemical staining of a multiple tissue array to examine the expression profile of JMJD2B. Our results demonstrate that JMJD2B protein levels were upregulated in malignant human tumors, including breast, colon, liver, and lung. Immunohistochemistry staining examination of liver tumor tissue microarray revealed that the expression of JMJD2B is significant according to the histological grade and TNM stage of liver tumor. Moreover, JMJD2B was also correlated with Ki-67 expression in HCC samples. These results reveal that JMJD2B is dramatically upregulated in HCC, making it a potential diagnostic marker for the further development of HCC treatment therapies. ? 2014 Elsevier GmbH.
SDGs
Other Subjects
histone demethylase; JMJD2B protein; Ki 67 antigen; tumor marker; unclassified drug; antigen expression; Article; brain cancer; breast cancer; cancer diagnosis; cancer grading; cancer patient; cancer staging; clinical feature; colon cancer; disease association; esophagus cancer; histopathology; human; human cell; human tissue; immunohistochemistry; kidney cancer; liver cancer; liver cell carcinoma; lung cancer; prostate cancer; protein expression; stomach cancer; tissue microarray; upregulation; uterus cancer
Type
journal article