Repository logo
  • English
  • 中文
Log In
Have you forgotten your password?
  1. Home
  2. College of Medicine / 醫學院
  3. Clinical Laboratory Sciences and Medical Biotechnology / 醫學檢驗暨生物技術學系所
  4. Sensitive measurement of quantity dynamics of FLT3 internal tandem duplication at early time points provides prognostic information
 
  • Details

Sensitive measurement of quantity dynamics of FLT3 internal tandem duplication at early time points provides prognostic information

Journal
Annals of Oncology
Journal Volume
22
Journal Issue
3
Pages
696-704
Date Issued
2011
Author(s)
WEN-CHIEN CHOU  
HSIN-AN HOU  
Liu C.-Y.
Chen C.-Y.
LIANG-IN LIN  
Huang Y.-N.
Chao Y.-C.
Hsu C.-A.
Huang C.-F.
HWEI-FANG TIEN  
DOI
10.1093/annonc/mdq402
URI
https://scholars.lib.ntu.edu.tw/handle/123456789/502695
Abstract
Background: The level of minimal residual disease (MRD) in acute myeloid leukemia (AML) at early time points (TPs) may be an important prognostic factor. Although internal tandem duplication of FLT3 (FLT3-ITD) as an MRD marker has been questioned for its instability based on semi-quantitative methods, we hypothesized that FLT3-ITD dynamics measured by sensitive quantitative real-time PCR at early TPs before appearance of instability may provide prognostic information. Patients and methods: We measured mutant quantity in 493 serial samples from 55 patients with a median followup time of 64.8 months. The FLT3-ITD quantities after induction (TP1) and after the first post-induction chemotherapy (TP2) were analyzed. Results: We found that lower FLT3-ITD levels at TP2 predicted longer overall survival (OS) and disease-free survival (DFS) regardless of cytogenetic risk. Multivariate analysis showed that ?3 log reduction of FLT3-ITD at TP2 independently predicted better DFS and a trend toward better OS. FLT3-ITD disappeared at relapse in 16.7% of patients and none in those harboring mutant NPM1 compared with 29.4% in those with wild-type NPM1 (P = 0.032). Conclusions: Though the mutation may disappear at relapse in a few patients, FLT3-ITD levels at early TPs after chemotherapy provide prognostic information. FLT3-ITD is significantly more stable in those with mutant NPM1. ? The Author 2010. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved.
SDGs

[SDGs]SDG3

Other Subjects
anthracycline; CD135 antigen; cytarabine; doxorubicin; idarubicin; nucleophosmin; retinoic acid; acute granulocytic leukemia; adolescent; adult; aged; article; cancer chemotherapy; cancer relapse; cancer survival; controlled study; disease free survival; drug megadose; female; gene duplication; gene mutation; genetic marker; human; internal tandem duplication; major clinical study; male; minimal residual disease; molecular dynamics; multiple cycle treatment; nucleotide sequence; outcome assessment; overall survival; priority journal; prognosis; quantitative study; sensitivity analysis; trend study; wild type; Adolescent; Adult; Aged; Aged, 80 and over; Amino Acid Sequence; Disease-Free Survival; Female; fms-Like Tyrosine Kinase 3; Genetic Association Studies; Genetic Markers; Humans; Kaplan-Meier Estimate; Leukemia, Myeloid, Acute; Male; Middle Aged; Molecular Sequence Data; Multivariate Analysis; Mutagenesis, Insertional; Neoplasm, Residual; Nuclear Proteins; Prognosis; Sequence Analysis, DNA; Young Adult
Type
journal article

臺大位居世界頂尖大學之列,為永久珍藏及向國際展現本校豐碩的研究成果及學術能量,圖書館整合機構典藏(NTUR)與學術庫(AH)不同功能平台,成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。

To permanently archive and promote researcher profiles and scholarly works, Library integrates the services of “NTU Repository” with “Academic Hub” to form NTU Scholars.

總館學科館員 (Main Library)
醫學圖書館學科館員 (Medical Library)
社會科學院辜振甫紀念圖書館學科館員 (Social Sciences Library)

開放取用是從使用者角度提升資訊取用性的社會運動,應用在學術研究上是透過將研究著作公開供使用者自由取閱,以促進學術傳播及因應期刊訂購費用逐年攀升。同時可加速研究發展、提升研究影響力,NTU Scholars即為本校的開放取用典藏(OA Archive)平台。(點選深入了解OA)

  • 請確認所上傳的全文是原創的內容,若該文件包含部分內容的版權非匯入者所有,或由第三方贊助與合作完成,請確認該版權所有者及第三方同意提供此授權。
    Please represent that the submission is your original work, and that you have the right to grant the rights to upload.
  • 若欲上傳已出版的全文電子檔,可使用Open policy finder網站查詢,以確認出版單位之版權政策。
    Please use Open policy finder to find a summary of permissions that are normally given as part of each publisher's copyright transfer agreement.
  • 網站簡介 (Quickstart Guide)
  • 使用手冊 (Instruction Manual)
  • 線上預約服務 (Booking Service)
  • 方案一:臺灣大學計算機中心帳號登入
    (With C&INC Email Account)
  • 方案二:ORCID帳號登入 (With ORCID)
  • 方案一:定期更新ORCID者,以ID匯入 (Search for identifier (ORCID))
  • 方案二:自行建檔 (Default mode Submission)
  • 方案三:學科館員協助匯入 (Email worklist to subject librarians)

Built with DSpace-CRIS software - Extension maintained and optimized by 4Science