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  1. NTU Scholars
  2. 醫學院
  3. 醫學檢驗暨生物技術學系
Please use this identifier to cite or link to this item: https://scholars.lib.ntu.edu.tw/handle/123456789/502720
Title: Marrow matrix metalloproteinases (MMPS) and tissue inhibitors of MMP in acute leukaemia: Potential role of MMP-9 as a surrogate marker to monitor leukaemic status in patients with acute myelogenous leukaemia
Authors: LIANG-IN LIN 
Lin D.-T.
Chang C.-J.
Lee C.-Y.
JIH-LUH TANG 
HWEI-FANG TIEN 
Issue Date: 2002
Journal Volume: 117
Journal Issue: 4
Start page/Pages: 835-841
Source: British Journal of Haematology
Abstract: 
Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) were demonstrated to have important implications in the progression and invasiveness of many malignant disorders. In contrast, the biological significance of these molecules in human leukaemias is not clear. We determined the levels of MMP-2, MMP-9, TIMP-1 and TIMP-2 in the bone marrow of 37 patients with acute myelogenous leukaemia (AML) and 18 patients with acute lymphoblastic leukaemia (ALL) before chemotherapy. Nineteen bone marrow donors served as normal controls. After chemotherapy, sequential measurements were done during the course in 19 AML patients. The levels of TIMP-1 and TIMP-2 were significantly higher and MMP-9 levels were significantly lower in the AML and ALL patients than in the normal controls. MMP-2 levels were higher in ALL, but not AML patients, compared with controls. Moreover, the levels of marrow MMP-2 and MMP-9 did not parallel the numbers of leukaemic blasts in the peripheral blood. MMP-9 levels were significantly lower in the AML patients who achieved a complete remission (CR) than in those who did not (8.71 ± 8.15 ng/ml vs 26.13 ± 27.75 ng/ml, P < 0.05). The AML patients with lower MMP-9 levels (? 4.4 ng/ml) tended to have longer survival time than those with higher levels (> 12 months vs 4 months, P = 0.12). In addition, MMP-9 levels in the AML patients at CR rose to the same range as the controls, but dropped again at relapse, demonstrating a close relationship of marrow MMP-9 with disease status of AML. Therefore, we conclude that the level of marrow MMP-9 may be a useful surrogate marker for monitoring disease status in AML and propose it as a potential prognostic factor.
URI: https://scholars.lib.ntu.edu.tw/handle/123456789/502720
ISSN: 0007-1048
DOI: 10.1046/j.1365-2141.2002.03510.x
SDG/Keyword: gelatinase A; gelatinase B; matrix metalloproteinase; tissue inhibitor of metalloproteinase; tissue inhibitor of metalloproteinase 1; tissue inhibitor of metalloproteinase 2; acute granulocytic leukemia; article; bone marrow; cancer chemotherapy; cancer recurrence; cancer regression; clinical article; controlled study; disease marker; human; human tissue; leukemia; leukemia cell; lymphatic leukemia; monitoring; priority journal; prognosis; protein determination; survival; tissue level; Analysis of Variance; Biological Markers; Bone Marrow; Case-Control Studies; Humans; Leukemia, Lymphocytic, Acute; Leukemia, Myelocytic, Acute; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Prognosis; Remission Induction; Statistics, Nonparametric; Survival Analysis; Tissue Inhibitor of Metalloproteinase-1; Tissue Inhibitor of Metalloproteinase-2; Tissue Inhibitor of Metalloproteinases
[SDGs]SDG3
Appears in Collections:醫學檢驗暨生物技術學系

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