Multimodal image-guided photothermal therapy mediated by 188Re-labeled micelles containing a cyanine-type photosensitizer
Journal
ACS Nano
Journal Volume
5
Journal Issue
7
Pages
5594-5607
Date Issued
2011
Author(s)
Abstract
Multifunctional micelles loaded with the near-infrared (NIR) dye and labeled with the radionuclide rhenium-188 (188Re) have been developed to provide multimodalities for NIR fluorescence and nuclear imaging and for photothermal therapy (PTT) of cancer. The NIR dye, IR-780 iodide, allowed the micelles to have dual functions in cancer NIR imaging and PTT. The 188Re-labeled IR-780 micelles enabled imaging by NIR fluorescence and by microSPECT to guide the delivery of drugs and to monitor in real-time the tumor accumulation, intratumoral distribution, and kinetics of drug release, which serve as a basis of specific photothermal injury to the targeted tissue. We also investigated the biodistribution, generation of heat, and photothermal cancer ablation of IR-780 micelles of both in vitro and in vivo xenografts. Histopathology observed irreversible tissue damage, such as necrotic features, decreased cell proliferation, increased apoptosis of cells, and increased expression of heat shock proteins in the PTT-treated tumors. The 188Re-labeled IR-780 micelles offer multifunctional modalities for NIR fluorescence and nuclear imaging and for PTT of cancer. ? 2011 American Chemical Society.
SDGs
Other Subjects
IR-780 iodide; Micro SPECT; Near-infrared fluorescence; Photothermal therapy; radiopharmaceuticals; rhenium-188 (188Re); Cell death; Cell proliferation; Diseases; Fluorescence; Infrared devices; Photosensitizers; Proteins; Rhenium; Tumors; Micelles; 2 (2 (2 chloro 3 ((1,3 dihydro 3,3 dimethyl 1 propyl 2H indol 2 ylidene)ethylidene) 1 cyclohexen 1 yl)ethenyl) 3,3 dimethyl 1 propylindolium; 2-(2-(2-chloro-3-((1,3-dihydro-3,3-dimethyl-1-propyl-2H-indol-2-ylidene)ethylidene)-1-cyclohexen-1-yl)ethenyl)-3,3-dimethyl-1-propylindolium; diagnostic agent; drug carrier; indole derivative; photosensitizing agent; radioisotope; rhenium; animal; article; cell strain HCT116; chemical structure; chemistry; colon tumor; conformation; female; human; isotope labeling; kinetics; light related phenomena; metabolism; methodology; micelle; molecular imaging; mouse; scintiscanning; single photon emission computer tomography; Animals; Colonic Neoplasms; Drug Carriers; Female; HCT116 Cells; Humans; Indoles; Isotope Labeling; Kinetics; Mice; Micelles; Models, Molecular; Molecular Conformation; Molecular Imaging; Optical Processes; Photosensitizing Agents; Radioisotopes; Rhenium; Tomography, Emission-Computed, Single-Photon
Type
conference paper