https://scholars.lib.ntu.edu.tw/handle/123456789/503541
標題: | Incidence of acute pancreatitis in human immunodeficiency virus-positive patients with hypertriglyceridemia: Is it really high? | 作者: | HSIN-YUN SUN SUI-YUAN CHANG WANG-HUEI SHENG Chen M.-Y. SZU-MIN HSIEH Tseng Y.-T. Lu C.-L. Yang C.-J. Wu H. Liu W.-C. Wu C.-H. CHIEN-CHING HUNG SHAN-CHWEN CHANG |
公開日期: | 2012 | 卷: | 41 | 期: | 2 | 起(迄)頁: | 283-289 | 來源出版物: | Pancreas | 摘要: | OBJECTIVE: To assess the incidence of acute pancreatitis in human immunodeficiency virus-positive patients with triglyceride (TG) greater than 500 mg/dL after highly active antiretroviral therapy. METHODS: Sequential TG levels during follow-up and episodes of acute pancreatitis were retrospectively reviewed in 347, 417, and 571 patients enrolled in periods 1 (2000-2002), 2 (2003-2005), and 3 (2006-2008), respectively. The incidence of acute pancreatitis, defined as consistent clinical symptoms and elevated amylase and/or lipase levels, was estimated. RESULTS: A total of 5356 TG measurements were performed during the follow-up for 698.22, 884.14, and 1215.69 person-years in periods 1, 2, and 3, respectively. Overall, 9.89% of patients had at least one TG greater than 500 mg/dL. Five patients with TG less than 500 mg/dL developed acute pancreatitis. The crude incidences of acute pancreatitis were 0.6%, 0.5%, and 0.2%, and the incidence rates were 2.86, 2.26, and 0.82/1000 person-years in periods 1, 2 and 3, respectively (all, P > 0.05). The incidence rates of acute pancreatitis when TG levels were less than 500, less than 1000, and less than 1500 mg/dL ranged from 1.2 to 4.9/1000 person-years, whereas it was 0/1000 person-years when TG levels were greater than 500, greater than 1000, and greater than 1500 mg/dL, respectively. CONCLUSION: The risk of acute pancreatitis was low among human immunodeficiency virus-positive patients who developed hypertriglyceridemia after receiving highly active antiretroviral therapy. Copyright ? 2012 by Lippincott Williams & Wilkins. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/503541 | ISSN: | 0885-3177 | DOI: | 10.1097/MPA.0b013e3182267fc0 | SDG/關鍵字: | abacavir; amylase; atazanavir; lopinavir plus ritonavir; tenofovir; triacylglycerol; triacylglycerol lipase; acute pancreatitis; adult; amylase blood level; article; controlled study; disease association; female; follow up; highly active antiretroviral therapy; human; Human immunodeficiency virus infection; human tissue; hypertriglyceridemia; major clinical study; male; priority journal; retrospective study; triacylglycerol blood level; triacylglycerol lipase blood level; virus load; Acute Disease; Adult; Amylases; Antiretroviral Therapy, Highly Active; Biological Markers; Chi-Square Distribution; Female; HIV Infections; Humans; Hypertriglyceridemia; Incidence; Lipase; Male; Middle Aged; Pancreatitis; Regression Analysis; Retrospective Studies; Risk Assessment; Risk Factors; Taiwan; Time Factors; Triglycerides; Young Adult |
顯示於: | 醫學檢驗暨生物技術學系 |
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