An uncommon case of HIV-1 transmission due to a knife fight
Journal
AIDS Research and Human Retroviruses
Journal Volume
27
Journal Issue
2
Pages
115-122
Date Issued
2011
Author(s)
Abstract
This article describes a case of human immunodeficiency virus type 1 (HIV-1) infection transmission caused by a bloody knife fight in a robbery. The victim was a 69-year-old man who was not infected with HIV-1, and his wife was HIV-antibody negative. A robber, a 42-year-old man, was HIV antibody-positive since December 2005 and had not taken antiretroviral therapy. The BED IgG Capture incidence EIA (BED-CEIA assay) data showed that the specimens from the victim were compatible with a recent seroconversion. Phylogenetic analysis of fragments of pol, encompassing protease and a portion of reverse transcriptase, and of env genes isolated from the victim, the robber, and a local population samples of HIV-1 positive individuals showed that the victim's HIV-1 sequences were most closely related to and nested within a lineage comprised of the robber's HIV-1 sequences. We provide HIV-1 seroconversion data and phylogenetic analysis as evidence that the HIV-1 transmission likely occurred from contact during the robbery. ? Copyright 2011, Mary Ann Liebert, Inc.
SDGs
Other Subjects
Human immunodeficiency virus antibody; immunoglobulin G; Pol protein; proteinase; RNA directed DNA polymerase; virus envelope protein; virus RNA; adult; aged; article; blood transfusion; case report; CD4 lymphocyte count; enzyme immunoassay; gene isolation; gene sequence; genetic analysis; human; Human immunodeficiency virus 1; Human immunodeficiency virus 1 infection; knife cut; male; molecular cloning; nucleotide sequence; phylogeny; priority journal; seroconversion; theft; virus gene; virus load; virus transmission; Adult; Aged; Base Sequence; Cloning, Molecular; DNA Primers; HIV Infections; HIV-1; Humans; Immunoenzyme Techniques; Male; Phylogeny; Wounds, Stab
Type
journal article