https://scholars.lib.ntu.edu.tw/handle/123456789/503551
標題: | An uncommon case of HIV-1 transmission due to a knife fight | 作者: | Kao C.-F. Hsia K.-T. SUI-YUAN CHANG Chang F.-Y. Nelson K. Yang C.-H. Huang Y.-F. Fu T.-Y. Yang J.-Y. |
公開日期: | 2011 | 卷: | 27 | 期: | 2 | 起(迄)頁: | 115-122 | 來源出版物: | AIDS Research and Human Retroviruses | 摘要: | This article describes a case of human immunodeficiency virus type 1 (HIV-1) infection transmission caused by a bloody knife fight in a robbery. The victim was a 69-year-old man who was not infected with HIV-1, and his wife was HIV-antibody negative. A robber, a 42-year-old man, was HIV antibody-positive since December 2005 and had not taken antiretroviral therapy. The BED IgG Capture incidence EIA (BED-CEIA assay) data showed that the specimens from the victim were compatible with a recent seroconversion. Phylogenetic analysis of fragments of pol, encompassing protease and a portion of reverse transcriptase, and of env genes isolated from the victim, the robber, and a local population samples of HIV-1 positive individuals showed that the victim's HIV-1 sequences were most closely related to and nested within a lineage comprised of the robber's HIV-1 sequences. We provide HIV-1 seroconversion data and phylogenetic analysis as evidence that the HIV-1 transmission likely occurred from contact during the robbery. ? Copyright 2011, Mary Ann Liebert, Inc. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/503551 | ISSN: | 0889-2229 | DOI: | 10.1089/aid.2010.0044 | SDG/關鍵字: | Human immunodeficiency virus antibody; immunoglobulin G; Pol protein; proteinase; RNA directed DNA polymerase; virus envelope protein; virus RNA; adult; aged; article; blood transfusion; case report; CD4 lymphocyte count; enzyme immunoassay; gene isolation; gene sequence; genetic analysis; human; Human immunodeficiency virus 1; Human immunodeficiency virus 1 infection; knife cut; male; molecular cloning; nucleotide sequence; phylogeny; priority journal; seroconversion; theft; virus gene; virus load; virus transmission; Adult; Aged; Base Sequence; Cloning, Molecular; DNA Primers; HIV Infections; HIV-1; Humans; Immunoenzyme Techniques; Male; Phylogeny; Wounds, Stab |
顯示於: | 醫學檢驗暨生物技術學系 |
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