https://scholars.lib.ntu.edu.tw/handle/123456789/504010
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Liao H.-J. | en_US |
dc.contributor.author | Chyuan I.-T. | en_US |
dc.contributor.author | Wu C.-S. | en_US |
dc.contributor.author | SHU-WHA LIN | en_US |
dc.contributor.author | Chen K.-H. | en_US |
dc.contributor.author | Tsai H.-F. | en_US |
dc.contributor.author | PING-NING HSU | en_US |
dc.creator | Liao H.-J.;Chyuan I.-T.;Wu C.-S.;Shu-Wha Lin;Chen K.-H.;Tsai H.-F.;Hsu P.-N. | - |
dc.date.accessioned | 2020-06-22T07:37:03Z | - |
dc.date.available | 2020-06-22T07:37:03Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 1462-0324 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/504010 | - |
dc.description.abstract | Objective. Proline-serine-threonine-phosphatase-interacting protein 2 (PSTPIP2) is involved in macrophage activation, neutrophil motility and osteoclast differentiation. However, the role of PSTPIP2 in inflammation and autoinflammatory diseases is still not clear. In this study, we generated PSTPIP2 knockout (Pstpip2-/-) mice to investigate its phenotype and role in autoinflammatory diseases. Methods. We constructed a Pstpip2-targeting vector and generated Pstpip2-/- mice. The phenotype and immunopathology of Pstpip2-/- mice were analysed. Results. All Pstpip2-/- mice developed paw swelling, synovitis, hyperostosis and osteitis, resembling SAPHO syndrome, an inflammatory disorder of the bone, skin and joints. Multifocal osteomyelitis was found in inflamed paws, with increased macrophage and marked neutrophil infiltrations in the bone, joint and skin. Profound osteolytic lesions with markedly decreased bone volume density developed in paws and limbs. Neutrophil-attracting chemokines and IL-1β were markedly elevated in inflamed tissues. Conclusion. Our study suggests that PSTPIP2 could play a role in innate immunity and development of autoinflammatory bone disorders, and may be associated with the pathogenesis of human SAPHO syndrome. ? The Author 2015. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. | - |
dc.relation.ispartof | Rheumatology (United Kingdom) | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | chemokine; interleukin 1; interleukin 1beta; proline serine threonine phosphatase interacting protein 2; protein; unclassified drug; animal experiment; animal model; animal tissue; arthritis; Article; autoinflammatory disease; bone atrophy; bone density; bone disease; bone mass; controlled study; cytokine production; dermatitis; gene targeting; gene vector; hyperostosis; immunopathology; innate immunity; knockout mouse; lymphadenopathy; macrophage; mouse; neutrophil chemotaxis; nonhuman; osteitis; osteomyelitis; pathogenesis; paw edema; phenotype; priority journal; SAPHO syndrome; splenomegaly; swelling; synovitis | - |
dc.title | Increased neutrophil infiltration, IL-1 production and a SAPHO syndrome-like phenotype in PSTPIP2-deficient mice | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1093/rheumatology/keu481 | - |
dc.identifier.pmid | 25602062 | - |
dc.identifier.scopus | 2-s2.0-84936883195 | - |
dc.relation.pages | 1317_1326 | - |
dc.relation.journalvolume | 54 | - |
dc.relation.journalissue | 7 | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
crisitem.author.dept | Clinical Laboratory Sciences and Medical Biotechnology | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.orcid | 0000-0001-6748-5581 | - |
crisitem.author.orcid | 0000-0003-4479-3391 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 醫學檢驗暨生物技術學系 |
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