https://scholars.lib.ntu.edu.tw/handle/123456789/504125
標題: | Subjective cognitive decline detected by the oscillatory connectivity in the default mode network: A magnetoencephalographic study | 作者: | Cheng C.-H. Wang P.-N. HUI-FEN MAO Hsiao F.-J. |
關鍵字: | Delta oscillation; Functional connectivity; Gamma oscillation; Resting state; Subjective memory complaint | 公開日期: | 2020 | 出版社: | Impact Journals LLC | 卷: | 12 | 期: | 4 | 起(迄)頁: | 3911-3925 | 來源出版物: | Aging | 摘要: | Discriminating between those with and without subjective cognitive decline (SCD) in cross-sectional investigations using neuropsychological tests is challenging. The available magnetoencephalographic (MEG) studies have demonstrated altered alpha-band spectral power and functional connectivity in those with SCD. However, whether the functional connectivity in other frequencies and brain networks, particularly the default mode network (DMN), exhibits abnormalities in SCD remains poorly understood. We recruited 26 healthy controls (HC) without SCD and 27 individuals with SCD to perform resting-state MEG recordings. The power of each frequency band and functional connectivity within the DMN were compared between these two groups. Posterior cingulate cortex (PCC)-based connectivity was also used to test its diagnostic accuracy as a predictor of SCD. There were no significant between-group differences of spectral power in the regional nodes. However, compared with HC, those with SCD demonstrated increased delta-band and gamma-band functional connectivity within the DMN. Moreover, node strength in the PCC exhibited a good discrimination ability at both delta and gamma frequencies. Our data suggest that the node strength of delta and gamma frequencies in the PCC may be a good neurophysiological marker in the discrimination of individuals with SCD from those without SCD. ? Cheng et al. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081944843&doi=10.18632%2faging.102859&partnerID=40&md5=bcab03d2430302c846221aa750ffa832 https://scholars.lib.ntu.edu.tw/handle/123456789/504125 |
ISSN: | 1945-4589 | DOI: | 10.18632/aging.102859 | SDG/關鍵字: | biological marker; aged; brain; cognitive defect; cross-sectional study; default mode network; diagnostic imaging; female; human; magnetoencephalography; male; middle aged; neuropsychological test; pathophysiology; Aged; Biomarkers; Brain; Cognitive Dysfunction; Cross-Sectional Studies; Default Mode Network; Female; Humans; Magnetoencephalography; Male; Middle Aged; Neuropsychological Tests |
顯示於: | 職能治療學系 |
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