https://scholars.lib.ntu.edu.tw/handle/123456789/504710
標題: | Cytoskeletal proteins in cancer and intracellular stress: A therapeutic perspective | 作者: | Ong M.S. Deng S. Halim C.E. Cai W. Tan T.Z. RUBY YUN-JU HUANG Sethi G. Hooi S.C. Kumar A.P. Yap C.T. |
關鍵字: | Cancer; Cytoskeletal molecules; Endoplasmic reticulum stress; Mitochondrial stress; Oxidative stress; Therapeutics | 公開日期: | 2020 | 出版社: | MDPI AG | 卷: | 12 | 期: | 1 | 起(迄)頁: | 238 | 來源出版物: | Cancers | 摘要: | Cytoskeletal proteins, which consist of different sub-families of proteins including microtubules, actin and intermediate filaments, are essential for survival and cellular processes in both normal as well as cancer cells. However, in cancer cells, these mechanisms can be altered to promote tumour development and progression, whereby the functions of cytoskeletal proteins are co-opted to facilitate increased migrative and invasive capabilities, proliferation, as well as resistance to cellular and environmental stresses. Herein, we discuss the cytoskeletal responses to important intracellular stresses (such as mitochondrial, endoplasmic reticulum and oxidative stresses), and delineate the consequences of these responses, including effects on oncogenic signalling. In addition, we elaborate how the cytoskeleton and its associated molecules present themselves as therapeutic targets. The potential and limitations of targeting new classes of cytoskeletal proteins are also explored, in the context of developing novel strategies that impact cancer progression. ? 2020 by the authors. Licensee MDPI, Basel, Switzerland. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079184412&doi=10.3390%2fcancers12010238&partnerID=40&md5=2b70e8abe98a3c2bb53408ea3d26ae82 https://scholars.lib.ntu.edu.tw/handle/123456789/504710 |
ISSN: | 2072-6694 | DOI: | 10.3390/cancers12010238 | SDG/關鍵字: | 1 ethyl 2 [[3 ethyl 5 (3 methylbenzothiazolin 2 ylidene) 4 oxothiazolidin 2 ylidene]methyl]pyridinium chloride; abituzumab; actin; cytochalasin; cytoskeleton protein; docetaxel; dynamin; dynamin related protein 1; epothilone derivative; gelsolin; histone deacetylase 6; histone deacetylase inhibitor; integrin; ixabepilone; jaspamide; LIM kinase; mitofusin 1; mitofusin 2; paclitaxel; proteasome inhibitor; salinomycin; silibinin; taxane derivative; tubacin; tubulin; unclassified drug; vimentin; Vinca alkaloid; voltage dependent anion channel; withaferin A; antiproliferative activity; cancer chemotherapy; cancer growth; cancer inhibition; cancer resistance; carcinogenesis; castration resistant prostate cancer; cell stress; DNA damage; drug potentiation; drug targeting; endoplasmic reticulum stress; epithelial mesenchymal transition; human; metastatic colorectal cancer; microfilament; microtubule; mitochondrial dynamics; mitochondrial fission; mitochondrial fusion; mitophagy; multiple myeloma; nonhuman; oxidative stress; proapoptotic activity; Review; signal transduction; tumor regression |
顯示於: | 醫學系 |
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