https://scholars.lib.ntu.edu.tw/handle/123456789/506308
標題: | Helical tomotherapy provides efficacy similar to that of intensity-modulated radiation therapy with dosimetric benefits for endometrial carcinoma | 作者: | Hsieh C.-H. Shueng P.-W. Hsiao S.-M. Wei M.-C. Wu W.-Y. Sun H.-D. Tien H.-J. LI-YING WANG Hsieh Y.-P. |
公開日期: | 2012 | 卷: | 5 | 起(迄)頁: | 245-253 | 來源出版物: | OncoTargets and Therapy | 摘要: | Background: The purpose of this study was to compare the efficacy of intensity-modulated radiotherapy (IMRT) and helical tomotherapy for endometrial cancer. Methods: Between November 1, 2006 and November 31, 2010, 31 patients with histologically confirmed endometrial cancer were enrolled. All enrolled patients received total abdominal hysterectomy and bilateral salpingo-oophorectomy with adjuvant whole pelvic IMRT or helical tomotherapy. Results: The actuarial 3-year overall survival, disease-free survival, locoregional control, and distant metastasis-free rates for the IMRT and helical tomotherapy groups were 87.5% versus 100%, 91.7% versus 51.7%, 91.7% versus 83.3%, and 91.7% versus 51.7%, respectively. The conformal index and uniformity index for IMRT versus helical tomotherapy was 1.25 versus 1.17 (P = 0.04) and 1.08 versus 1.05 (P<0.01), respectively. Two of 31 patients with cervical stump failure were noted, one in the IMRT group and the other in the helical tomotherapy group. No acute or late grade 3 or 4 toxicities were noted, including proctitis, or genitourinary or gastrointestinal disturbances. Conclusion: Helical tomotherapy is as effective as IMRT and has better uniformity and conformal indices, and critical organ-sparing properties. Prospective clinical trials are needed to evaluate the comparative efficacy of IMRT versus helical tomotherapy. ? 2012 Hsieh et al, publisher and licensee Dove Medical Press Ltd. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84873886301&doi=10.2147%2fOTT.S35958&partnerID=40&md5=ae28bdd319417f30155d9457477d7705 https://scholars.lib.ntu.edu.tw/handle/123456789/506308 |
ISSN: | 1178-6930 | DOI: | 10.2147/OTT.S35958 | SDG/關鍵字: | abdominal hysterectomy; adult; aged; article; brachytherapy; cancer adjuvant therapy; cancer radiotherapy; cancer recurrence; cancer survival; clinical article; comparative effectiveness; controlled study; diarrhea; disease free survival; distant metastasis free survival; dosimetry; endometrium carcinoma; female; human; intensity modulated radiation therapy; leukopenia; local recurrence free survival; metastasis; overall survival; pain; radiation injury; radiotherapy equipment; retrospective study; salpingooophorectomy; tomotherapy; treatment outcome |
顯示於: | 物理治療學系所 |
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